Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons

Eric M. Prager; Daniel B. Dorman; Zachary B. Hobel; Jeffrey M. Malgady; Kim T. Blackwell; Joshua L. Plotkin

doi:10.1016/j.neuron.2020.09.028

Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons

Eric M. Prager
, Daniel B. Dorman
, Zachary B. Hobel
, Jeffrey M. Malgady
, Kim T. Blackwell
, Joshua L. Plotkin

Neurobiology and Behavior

Stony Brook University
George Mason University

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Prager et al. show that dopamine promotes the maintenance of dendritically evoked “up-states” in mouse direct pathway matrix SPNs but opposes it in striosomes. This requires postsynaptic D1 receptors and involves differential engagement of L-type Ca²⁺ channels. These findings reveal a mechanism where fluctuations in dopamine may constrain compartment-specific striatal output.

Original language	English
Pages (from-to)	1091-1102.e5
Journal	Neuron
Volume	108
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2020.09.028
State	Published - Dec 23 2020

Keywords

2-photon imaging
dendrite
L-type calcium channel
model
plateau
state-transition
striatum
synaptic integration
up-state
voltage-gated calcium channel

Access to Document

10.1016/j.neuron.2020.09.028

Cite this

@article{5aec1f2dc5f14e5a818e7a03f61dc960,

title = "Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons",

abstract = "Prager et al. show that dopamine promotes the maintenance of dendritically evoked “up-states” in mouse direct pathway matrix SPNs but opposes it in striosomes. This requires postsynaptic D1 receptors and involves differential engagement of L-type Ca2+ channels. These findings reveal a mechanism where fluctuations in dopamine may constrain compartment-specific striatal output.",

keywords = "2-photon imaging, dendrite, L-type calcium channel, model, plateau, state-transition, striatum, synaptic integration, up-state, voltage-gated calcium channel",

author = "Prager, \{Eric M.\} and Dorman, \{Daniel B.\} and Hobel, \{Zachary B.\} and Malgady, \{Jeffrey M.\} and Blackwell, \{Kim T.\} and Plotkin, \{Joshua L.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = dec,

day = "23",

doi = "10.1016/j.neuron.2020.09.028",

language = "English",

volume = "108",

pages = "1091--1102.e5",

journal = "Neuron",

issn = "0896-6273",

number = "6",

}

TY - JOUR

T1 - Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons

AU - Prager, Eric M.

AU - Dorman, Daniel B.

AU - Hobel, Zachary B.

AU - Malgady, Jeffrey M.

AU - Blackwell, Kim T.

AU - Plotkin, Joshua L.

PY - 2020/12/23

Y1 - 2020/12/23

N2 - Prager et al. show that dopamine promotes the maintenance of dendritically evoked “up-states” in mouse direct pathway matrix SPNs but opposes it in striosomes. This requires postsynaptic D1 receptors and involves differential engagement of L-type Ca2+ channels. These findings reveal a mechanism where fluctuations in dopamine may constrain compartment-specific striatal output.

AB - Prager et al. show that dopamine promotes the maintenance of dendritically evoked “up-states” in mouse direct pathway matrix SPNs but opposes it in striosomes. This requires postsynaptic D1 receptors and involves differential engagement of L-type Ca2+ channels. These findings reveal a mechanism where fluctuations in dopamine may constrain compartment-specific striatal output.

KW - 2-photon imaging

KW - dendrite

KW - L-type calcium channel

KW - model

KW - plateau

KW - state-transition

KW - striatum

KW - synaptic integration

KW - up-state

KW - voltage-gated calcium channel

UR - https://www.scopus.com/pages/publications/85095420829

U2 - 10.1016/j.neuron.2020.09.028

DO - 10.1016/j.neuron.2020.09.028

M3 - Article

C2 - 33080228

AN - SCOPUS:85095420829

SN - 0896-6273

VL - 108

SP - 1091-1102.e5

JO - Neuron

JF - Neuron

IS - 6

ER -

Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this