Double minutes in the papillary thyroid cancer cell line PTC-1113A

Marille E. Herrmann; Peter A. Lalley; Linea L. Rydstedt; Eckart Meese; Charles H. Lang; Naji N. Abumrad; Ute M. Moll; Gary B. Talpos

doi:10.1016/0165-4608(96)00048-9

Double minutes in the papillary thyroid cancer cell line PTC-1113A

Marille E. Herrmann
, Peter A. Lalley
, Linea L. Rydstedt
, Eckart Meese
, Charles H. Lang
, Naji N. Abumrad
, Ute M. Moll
, Gary B. Talpos

Pathology

Stony Brook University
Henry Ford Health System
The University of Chicago
Wayne State University
Rochester Institute of Technology
Saarland University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.

Original language	English
Pages (from-to)	70-74
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(96)00048-9
State	Published - Aug 1996

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title = "Double minutes in the papillary thyroid cancer cell line PTC-1113A",

abstract = "The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.",

author = "Herrmann, \{Marille E.\} and Lalley, \{Peter A.\} and Rydstedt, \{Linea L.\} and Eckart Meese and Lang, \{Charles H.\} and Abumrad, \{Naji N.\} and Moll, \{Ute M.\} and Talpos, \{Gary B.\}",

year = "1996",

month = aug,

doi = "10.1016/0165-4608(96)00048-9",

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T1 - Double minutes in the papillary thyroid cancer cell line PTC-1113A

AU - Herrmann, Marille E.

AU - Lalley, Peter A.

AU - Rydstedt, Linea L.

AU - Meese, Eckart

AU - Lang, Charles H.

AU - Abumrad, Naji N.

AU - Moll, Ute M.

AU - Talpos, Gary B.

PY - 1996/8

Y1 - 1996/8

N2 - The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.

AB - The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.

UR - https://www.scopus.com/pages/publications/0030221391

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DO - 10.1016/0165-4608(96)00048-9

M3 - Article

C2 - 8780751

AN - SCOPUS:0030221391

SN - 0165-4608

VL - 90

SP - 70

EP - 74

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Double minutes in the papillary thyroid cancer cell line PTC-1113A

Abstract

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