Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK

Ming Wang; Chenglong Li; Hui Nie; Xin Lv; Ying Qu; Beiqin Yu; Liping Su; Jianfang Li; Xuehua Chen; Jingfang Ju; Yingyan Yu; Min Yan; Qinlong Gu; Zhenggang Zhu; Bingya Liu

doi:10.1016/j.febslet.2012.05.050

Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK

Ming Wang
, Chenglong Li
, Hui Nie
, Xin Lv
, Ying Qu
, Beiqin Yu
, Liping Su
, Jianfang Li
, Xuehua Chen
, Jingfang Ju
, Yingyan Yu
, Min Yan
, Qinlong Gu
, Zhenggang Zhu
, Bingya Liu

Pathology

Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis. Crown

Original language	English
Pages (from-to)	2382-2388
Number of pages	7
Journal	FEBS Letters
Volume	586
Issue number	16
DOIs	https://doi.org/10.1016/j.febslet.2012.05.050
State	Published - Jul 30 2012

Keywords

Gastric cancer
ILK
Invasion
Metastasis
miR-625
miRNA

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10.1016/j.febslet.2012.05.050

Cite this

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title = "Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK",

abstract = "Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis. Crown",

keywords = "Gastric cancer, ILK, Invasion, Metastasis, miR-625, miRNA",

author = "Ming Wang and Chenglong Li and Hui Nie and Xin Lv and Ying Qu and Beiqin Yu and Liping Su and Jianfang Li and Xuehua Chen and Jingfang Ju and Yingyan Yu and Min Yan and Qinlong Gu and Zhenggang Zhu and Bingya Liu",

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doi = "10.1016/j.febslet.2012.05.050",

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TY - JOUR

T1 - Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK

AU - Wang, Ming

AU - Li, Chenglong

AU - Nie, Hui

AU - Lv, Xin

AU - Qu, Ying

AU - Yu, Beiqin

AU - Su, Liping

AU - Li, Jianfang

AU - Chen, Xuehua

AU - Ju, Jingfang

AU - Yu, Yingyan

AU - Yan, Min

AU - Gu, Qinlong

AU - Zhu, Zhenggang

AU - Liu, Bingya

PY - 2012/7/30

Y1 - 2012/7/30

N2 - Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis. Crown

AB - Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis. Crown

KW - Gastric cancer

KW - ILK

KW - Invasion

KW - Metastasis

KW - miR-625

KW - miRNA

UR - https://www.scopus.com/pages/publications/84864287425

U2 - 10.1016/j.febslet.2012.05.050

DO - 10.1016/j.febslet.2012.05.050

M3 - Article

C2 - 22677169

AN - SCOPUS:84864287425

SN - 0014-5793

VL - 586

SP - 2382

EP - 2388

JO - FEBS Letters

JF - FEBS Letters

IS - 16

ER -

Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK

Abstract

Keywords

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