Early life stress, physiology, and genetics: A review

Nia Fogelman; Turhan Canli

doi:10.3389/fpsyg.2019.01668

Early life stress, physiology, and genetics: A review

Nia Fogelman
, Turhan Canli

Psychology

Yale University
Stony Brook University

Research output: Contribution to journal › Short survey › peer-review

60 Scopus citations

Abstract

Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous system, hypothalamic pituitary adrenal axis, and markers of inflammation related to immune function in both human and animal literature. We also consider the potential role of genetic and epigenetic factors on the ELS- health outcome relationship. We conclude with recommendations to overcome identified shortcomings in a field that seeks to address the health consequences of ELS.

Original language	English
Article number	1668
Journal	Frontiers in Psychology
Volume	10
Issue number	JULY
DOIs	https://doi.org/10.3389/fpsyg.2019.01668
State	Published - 2019

Keywords

Early life stress (ELS)
Epigenetics
Genetics
Hypothalamic pituitary adrenal (HPA) axis
Inflammation
Sympathetic nervous system (SNS)

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10.3389/fpsyg.2019.01668

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abstract = "Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous system, hypothalamic pituitary adrenal axis, and markers of inflammation related to immune function in both human and animal literature. We also consider the potential role of genetic and epigenetic factors on the ELS- health outcome relationship. We conclude with recommendations to overcome identified shortcomings in a field that seeks to address the health consequences of ELS.",

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KW - Epigenetics

KW - Genetics

KW - Hypothalamic pituitary adrenal (HPA) axis

KW - Inflammation

KW - Sympathetic nervous system (SNS)

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JO - Frontiers in Psychology

JF - Frontiers in Psychology

IS - JULY

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ER -

Early life stress, physiology, and genetics: A review

Abstract

Keywords

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