ECD peptides inhibit in vitro fertilization in mice

Amy Pyluck; Ruiyong Yuan; Edward Galligan; Paul Primakoff; Diana G. Myles; Nicole S. Sampson

doi:10.1016/S0960-894X(97)00160-1

ECD peptides inhibit in vitro fertilization in mice

Amy Pyluck
, Ruiyong Yuan
, Edward Galligan
, Paul Primakoff
, Diana G. Myles
, Nicole S. Sampson

Chemistry

Stony Brook University
University of California at Davis

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Cyclic and linear peptides containing the conserved ECD sequence from the disintegrin domain of the β-subunit of fertilin were synthesized and tested as inhibitors of sperm-egg fusion in in vitro mouse fertilization assays. At 500 μM concentrations, reduced ECD peptides inhibited fertilization, whereas oxidized dimers did not. Control peptides suggest that more than three amino acids of the disintegrin domain are recognized by its receptor.

Original language	English
Pages (from-to)	1053-1058
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(97)00160-1
State	Published - Apr 22 1997

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10.1016/S0960-894X(97)00160-1

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title = "ECD peptides inhibit in vitro fertilization in mice",

abstract = "Cyclic and linear peptides containing the conserved ECD sequence from the disintegrin domain of the β-subunit of fertilin were synthesized and tested as inhibitors of sperm-egg fusion in in vitro mouse fertilization assays. At 500 μM concentrations, reduced ECD peptides inhibited fertilization, whereas oxidized dimers did not. Control peptides suggest that more than three amino acids of the disintegrin domain are recognized by its receptor.",

author = "Amy Pyluck and Ruiyong Yuan and Edward Galligan and Paul Primakoff and Myles, \{Diana G.\} and Sampson, \{Nicole S.\}",

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doi = "10.1016/S0960-894X(97)00160-1",

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T1 - ECD peptides inhibit in vitro fertilization in mice

AU - Pyluck, Amy

AU - Yuan, Ruiyong

AU - Galligan, Edward

AU - Primakoff, Paul

AU - Myles, Diana G.

AU - Sampson, Nicole S.

PY - 1997/4/22

Y1 - 1997/4/22

N2 - Cyclic and linear peptides containing the conserved ECD sequence from the disintegrin domain of the β-subunit of fertilin were synthesized and tested as inhibitors of sperm-egg fusion in in vitro mouse fertilization assays. At 500 μM concentrations, reduced ECD peptides inhibited fertilization, whereas oxidized dimers did not. Control peptides suggest that more than three amino acids of the disintegrin domain are recognized by its receptor.

AB - Cyclic and linear peptides containing the conserved ECD sequence from the disintegrin domain of the β-subunit of fertilin were synthesized and tested as inhibitors of sperm-egg fusion in in vitro mouse fertilization assays. At 500 μM concentrations, reduced ECD peptides inhibited fertilization, whereas oxidized dimers did not. Control peptides suggest that more than three amino acids of the disintegrin domain are recognized by its receptor.

UR - https://www.scopus.com/pages/publications/0030894662

U2 - 10.1016/S0960-894X(97)00160-1

DO - 10.1016/S0960-894X(97)00160-1

M3 - Article

AN - SCOPUS:0030894662

SN - 0960-894X

VL - 7

SP - 1053

EP - 1058

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

ECD peptides inhibit in vitro fertilization in mice

Abstract

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