Effect of gulping down Bisacodyl prior to oral taking compound polyethylene glycol-4000 for preparation of CT colonography

Objective: To explore the effect of gulping down 10 mg bisacodyl prior to oral taking compound polyethylene glycol-4000 for preparation of CT colonography. Methods: Forty patients who underwent CT colonography were assigned to experiment or control group randomly. On the day before CT colonography, patients in experiment group orally took 20 ml of 40% W/V barium sulfate before 3 mealtime and 20 ml of 60% diatrizoate meglumine diluted in 250 ml of water after dinner, then gulped down 10 mg bisacodyl enteric-coated tablets 1 h before oral administration of 2 liter compound polyethylene glycol-4000 electrolyte solution. Patients in control group were identical to experiment group except of not taking bisacodyl. The remnant fluid scores, attenuation value of remnant fluid and residual stool scores between two groups were analyzed statistically. Results: The average score of remnant fluid of experiment group (1.50±0.06) was lower than that of control group (1.78±0.08, P=0.024). The mean attenuation value of residual fluid of experiment group and control group was (729±29)HU and (597±27)HU, respectively (P>0.05). The mean score of remnant stool of experiment group (1.96±0.11) was lower than that of control group (2.63±0.12, P=0.001). Conclusion: Gulping down bisacodyl before oral taking compound polyethylene glycol-4000 can increase the ability to cleansing fluid without impact on the attenuation value of residual fluid, and improve the capability of clearing away remnant stool with better bowel cleansing than oral administration of compound polyethylene glycol-4000 alone, therefore is a fine way for colorectal preparation of CT colonography.