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Effective method for the asymmetric synthesis of bis-β-lactams by the cycloaddition of azidoketen to benzylideneamines bearing a chiral β-lactam backbone

  • Sagami Chemical Research Institute

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Extremely high stereoselectivity was observed in the asymmetric cycloaddition of azidoketen to 1-[(S)-1-t-butoxycarbonylethyl]-3- benzylideneamino-4-phenyl-azetidin-2-ones, which gave rise to the formation of optically pure bis-β-lactams.

Original languageEnglish
Pages (from-to)344-346
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number7
DOIs
StatePublished - 1981

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