Effects of a grcwth hormone releasing factor in man

Marie C. Gelato; Ora Pescovitz; Fernando Cassorla; D. Lynn Fernando; George R. Merriam

doi:10.1210/jcem-57-3-674

Effects of a grcwth hormone releasing factor in man

Marie C. Gelato
, Ora Pescovitz
, Fernando Cassorla
, D. Lynn Fernando
, George R. Merriam

Endocrinology and Metabolism

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

The effects of the 44-amino acid growth hormone releasing factor (GRF-44) were tested in normal adult men and women. At a dose of 1 μg/kg intravenous boluses of GRF-44 stimulated prompt elevations of plasma GH, which in 5 men reached maximum levels of 34 ± 28 (S.D.) ng/ml, and in 3 women in the mid-follicular phase, 53 ± 10 ng/ml. The action of GRF was highly selective; there were no changes in plasma PRL, W, FSH, TSH, or cortisol at this dose level. Side effects, mostly flushing and a sense of warmth of the face and chest, were mild and occurred only in a minority of subjects.

Original language	English
Pages (from-to)	674-676
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	57
Issue number	3
DOIs	https://doi.org/10.1210/jcem-57-3-674
State	Published - Sep 1983

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title = "Effects of a grcwth hormone releasing factor in man",

abstract = "The effects of the 44-amino acid growth hormone releasing factor (GRF-44) were tested in normal adult men and women. At a dose of 1 μg/kg intravenous boluses of GRF-44 stimulated prompt elevations of plasma GH, which in 5 men reached maximum levels of 34 ± 28 (S.D.) ng/ml, and in 3 women in the mid-follicular phase, 53 ± 10 ng/ml. The action of GRF was highly selective; there were no changes in plasma PRL, W, FSH, TSH, or cortisol at this dose level. Side effects, mostly flushing and a sense of warmth of the face and chest, were mild and occurred only in a minority of subjects.",

author = "Gelato, \{Marie C.\} and Ora Pescovitz and Fernando Cassorla and Fernando, \{D. Lynn\} and Merriam, \{George R.\}",

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AU - Gelato, Marie C.

AU - Pescovitz, Ora

AU - Cassorla, Fernando

AU - Fernando, D. Lynn

AU - Merriam, George R.

PY - 1983/9

Y1 - 1983/9

N2 - The effects of the 44-amino acid growth hormone releasing factor (GRF-44) were tested in normal adult men and women. At a dose of 1 μg/kg intravenous boluses of GRF-44 stimulated prompt elevations of plasma GH, which in 5 men reached maximum levels of 34 ± 28 (S.D.) ng/ml, and in 3 women in the mid-follicular phase, 53 ± 10 ng/ml. The action of GRF was highly selective; there were no changes in plasma PRL, W, FSH, TSH, or cortisol at this dose level. Side effects, mostly flushing and a sense of warmth of the face and chest, were mild and occurred only in a minority of subjects.

AB - The effects of the 44-amino acid growth hormone releasing factor (GRF-44) were tested in normal adult men and women. At a dose of 1 μg/kg intravenous boluses of GRF-44 stimulated prompt elevations of plasma GH, which in 5 men reached maximum levels of 34 ± 28 (S.D.) ng/ml, and in 3 women in the mid-follicular phase, 53 ± 10 ng/ml. The action of GRF was highly selective; there were no changes in plasma PRL, W, FSH, TSH, or cortisol at this dose level. Side effects, mostly flushing and a sense of warmth of the face and chest, were mild and occurred only in a minority of subjects.

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EP - 676

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 3

ER -

Effects of a grcwth hormone releasing factor in man

Abstract

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