Effects of low intrapulmonary PCO2 on ventilatory sensitivity to PaCO2 in chickens

T. P. Adamson; I. C. Solomon

doi:10.1016/0034-5687(93)90045-C

Effects of low intrapulmonary P_CO₂ on ventilatory sensitivity to Pa_CO₂ in chickens

T. P. Adamson
, I. C. Solomon

Physiology and Biophysics

University of California at Davis

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We found conflicting reports regarding the relationship between intrapulmonary P_CO₂ and sensitivity to Pa_CO₂ in the chicken. To resolve this, we anesthetized eight cockerels with sodium pentobarbital (25-35 mg/kg), cannulated the cutaneous ulnar vein and carotid artery, opened the thorax and ventilated right and left lungs independently. We established Pa_CO₂ by over-ventilating the denervated, perfused right lung with the following: 94.7, 39.9, 31.6 and 19.0 Torr P_CO₂ balanced with oxygen. At each right lung CO₂ tension (PR_CO₂), we measured blood pressure and ventilatory responses to five CO₂ tensions (PL_CO₂) ventilating the non-perfused left lung. PL_CO₂ ranged from 70.3 to 15.7 Torr. We found a linear relationship between the amplitude of sternal deflections and Pa_CO₂^-1, andthat the slope depended upon PL_CO₂. Respiratory period was also linearly related to Pa_CO₂^-1, however the intercept, not the slope, was a altered by PL_CO₂. Stepwise regression analyses revealed an important interaction term (that is, (Pa_CO₂·PL_CO₂)^{- 1}) in the determination of respiratory amplitude, but not in the determination of period. We conclude that low intrapulmonary P_CO₂ enhances the sensitivity of respiratory amplitude to changes in Pa_CO₂. Further, we propose that intrapulmonary chemoreceptor discharge mediates this change in sensitivity to Pa_CO₂.

Original language	English
Pages (from-to)	163-171
Number of pages	9
Journal	Respiration Physiology
Volume	94
Issue number	2
DOIs	https://doi.org/10.1016/0034-5687(93)90045-C
State	Published - Nov 1993

Keywords

Birds, chicken
Carbon dioxide, sensitivity respiration
Chemoreceptors, arterial, intrapulmonary
Control of breathing, pulmonary vs arterial CO sensitivity

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10.1016/0034-5687(93)90045-C

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title = "Effects of low intrapulmonary PCO2 on ventilatory sensitivity to PaCO2 in chickens",

abstract = "We found conflicting reports regarding the relationship between intrapulmonary PCO2 and sensitivity to PaCO2 in the chicken. To resolve this, we anesthetized eight cockerels with sodium pentobarbital (25-35 mg/kg), cannulated the cutaneous ulnar vein and carotid artery, opened the thorax and ventilated right and left lungs independently. We established PaCO2 by over-ventilating the denervated, perfused right lung with the following: 94.7, 39.9, 31.6 and 19.0 Torr PCO2 balanced with oxygen. At each right lung CO2 tension (PRCO2), we measured blood pressure and ventilatory responses to five CO2 tensions (PLCO2) ventilating the non-perfused left lung. PLCO2 ranged from 70.3 to 15.7 Torr. We found a linear relationship between the amplitude of sternal deflections and PaCO2-1, andthat the slope depended upon PLCO2. Respiratory period was also linearly related to PaCO2-1, however the intercept, not the slope, was a altered by PLCO2. Stepwise regression analyses revealed an important interaction term (that is, (PaCO2·PLCO2)- 1) in the determination of respiratory amplitude, but not in the determination of period. We conclude that low intrapulmonary PCO2 enhances the sensitivity of respiratory amplitude to changes in PaCO2. Further, we propose that intrapulmonary chemoreceptor discharge mediates this change in sensitivity to PaCO2.",

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AU - Adamson, T. P.

AU - Solomon, I. C.

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N2 - We found conflicting reports regarding the relationship between intrapulmonary PCO2 and sensitivity to PaCO2 in the chicken. To resolve this, we anesthetized eight cockerels with sodium pentobarbital (25-35 mg/kg), cannulated the cutaneous ulnar vein and carotid artery, opened the thorax and ventilated right and left lungs independently. We established PaCO2 by over-ventilating the denervated, perfused right lung with the following: 94.7, 39.9, 31.6 and 19.0 Torr PCO2 balanced with oxygen. At each right lung CO2 tension (PRCO2), we measured blood pressure and ventilatory responses to five CO2 tensions (PLCO2) ventilating the non-perfused left lung. PLCO2 ranged from 70.3 to 15.7 Torr. We found a linear relationship between the amplitude of sternal deflections and PaCO2-1, andthat the slope depended upon PLCO2. Respiratory period was also linearly related to PaCO2-1, however the intercept, not the slope, was a altered by PLCO2. Stepwise regression analyses revealed an important interaction term (that is, (PaCO2·PLCO2)- 1) in the determination of respiratory amplitude, but not in the determination of period. We conclude that low intrapulmonary PCO2 enhances the sensitivity of respiratory amplitude to changes in PaCO2. Further, we propose that intrapulmonary chemoreceptor discharge mediates this change in sensitivity to PaCO2.

AB - We found conflicting reports regarding the relationship between intrapulmonary PCO2 and sensitivity to PaCO2 in the chicken. To resolve this, we anesthetized eight cockerels with sodium pentobarbital (25-35 mg/kg), cannulated the cutaneous ulnar vein and carotid artery, opened the thorax and ventilated right and left lungs independently. We established PaCO2 by over-ventilating the denervated, perfused right lung with the following: 94.7, 39.9, 31.6 and 19.0 Torr PCO2 balanced with oxygen. At each right lung CO2 tension (PRCO2), we measured blood pressure and ventilatory responses to five CO2 tensions (PLCO2) ventilating the non-perfused left lung. PLCO2 ranged from 70.3 to 15.7 Torr. We found a linear relationship between the amplitude of sternal deflections and PaCO2-1, andthat the slope depended upon PLCO2. Respiratory period was also linearly related to PaCO2-1, however the intercept, not the slope, was a altered by PLCO2. Stepwise regression analyses revealed an important interaction term (that is, (PaCO2·PLCO2)- 1) in the determination of respiratory amplitude, but not in the determination of period. We conclude that low intrapulmonary PCO2 enhances the sensitivity of respiratory amplitude to changes in PaCO2. Further, we propose that intrapulmonary chemoreceptor discharge mediates this change in sensitivity to PaCO2.

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KW - Carbon dioxide, sensitivity respiration

KW - Chemoreceptors, arterial, intrapulmonary

KW - Control of breathing, pulmonary vs arterial CO sensitivity

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ER -

Effects of low intrapulmonary P_CO₂ on ventilatory sensitivity to Pa_CO₂ in chickens

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