Effects of Sperm‐Reactive Monoclonal Antibodies on the Cervical Mucus Penetrating Ability of Human Spermatozoa

RICHARD A. BRONSON; GEORGE W. COOPER

doi:10.1111/j.1600-0897.1987.tb00119.x

Effects of Sperm‐Reactive Monoclonal Antibodies on the Cervical Mucus Penetrating Ability of Human Spermatozoa

RICHARD A. BRONSON
, GEORGE W. COOPER

Obstetrics and Gynecology

Northwell Health System

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

ABSTRACT: A group of monoclonal antibodies (Mabs) was tested by immunobead binding and indirect immunofluorescence to determine its reactivity with antigenic moieties present either on the surface of motile human spermatozoa or internally. Those Mabs reactive with the surface of motile spermatozoa impaired their ability to penetrate cervical mucus in vitro, while Mabs solely reactive with freeze‐thawed, nonmotile sperm (presumptive subsurface epitopes) were without effect on sperm function. 1987 Munksgaard

Original language	English
Pages (from-to)	59-61
Number of pages	3
Journal	American journal of reproductive immunology and microbiology : AJRIM
Volume	14
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0897.1987.tb00119.x
State	Published - Jun 1987

Keywords

cervical mucus penetration
specific epitopes
Sperm function
sperm surface antigens

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10.1111/j.1600-0897.1987.tb00119.x

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AU - COOPER, GEORGE W.

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AB - ABSTRACT: A group of monoclonal antibodies (Mabs) was tested by immunobead binding and indirect immunofluorescence to determine its reactivity with antigenic moieties present either on the surface of motile human spermatozoa or internally. Those Mabs reactive with the surface of motile spermatozoa impaired their ability to penetrate cervical mucus in vitro, while Mabs solely reactive with freeze‐thawed, nonmotile sperm (presumptive subsurface epitopes) were without effect on sperm function. 1987 Munksgaard

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KW - specific epitopes

KW - Sperm function

KW - sperm surface antigens

UR - https://www.scopus.com/pages/publications/0023227147

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Effects of Sperm‐Reactive Monoclonal Antibodies on the Cervical Mucus Penetrating Ability of Human Spermatozoa

Abstract

Keywords

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