Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival

Elliot Regenbogen; Michelle Mo; Jamie Romeiser; A. Laurie W. Shroyer; Luisa F. Escobar-Hoyos; Stephanie Burke; Kenneth R. Shroyer

doi:10.1002/hed.25164

Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival

Elliot Regenbogen
, Michelle Mo
, Jamie Romeiser
, A. Laurie W. Shroyer
, Luisa F. Escobar-Hoyos
, Stephanie Burke
, Kenneth R. Shroyer

Stony Brook University

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. Methods: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR). Results: Elevated K17 expression was significantly associated with an overall decreased patient survival (P =.02) and, more specifically, in patients with oropharyngeal SCC (P =.01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P =.01). Conclusion: Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.

Original language	English
Pages (from-to)	1788-1798
Number of pages	11
Journal	Head and Neck
Volume	40
Issue number	8
DOIs	https://doi.org/10.1002/hed.25164
State	Published - Aug 2018

Keywords

biomarker
head and neck
head and neck carcinoma
immunopathology
keratin 17

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10.1002/hed.25164

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@article{a81a97626763421eab57b0f3469b8549,

title = "Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival",

abstract = "Background: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. Methods: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR). Results: Elevated K17 expression was significantly associated with an overall decreased patient survival (P =.02) and, more specifically, in patients with oropharyngeal SCC (P =.01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P =.01). Conclusion: Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.",

keywords = "biomarker, head and neck, head and neck carcinoma, immunopathology, keratin 17",

author = "Elliot Regenbogen and Michelle Mo and Jamie Romeiser and Shroyer, \{A. Laurie W.\} and Escobar-Hoyos, \{Luisa F.\} and Stephanie Burke and Shroyer, \{Kenneth R.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

month = aug,

doi = "10.1002/hed.25164",

language = "English",

volume = "40",

pages = "1788--1798",

journal = "Head and Neck",

issn = "1043-3074",

number = "8",

}

TY - JOUR

T1 - Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival

AU - Regenbogen, Elliot

AU - Mo, Michelle

AU - Romeiser, Jamie

AU - Shroyer, A. Laurie W.

AU - Escobar-Hoyos, Luisa F.

AU - Burke, Stephanie

AU - Shroyer, Kenneth R.

PY - 2018/8

Y1 - 2018/8

N2 - Background: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. Methods: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR). Results: Elevated K17 expression was significantly associated with an overall decreased patient survival (P =.02) and, more specifically, in patients with oropharyngeal SCC (P =.01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P =.01). Conclusion: Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.

AB - Background: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. Methods: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR). Results: Elevated K17 expression was significantly associated with an overall decreased patient survival (P =.02) and, more specifically, in patients with oropharyngeal SCC (P =.01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P =.01). Conclusion: Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.

KW - biomarker

KW - head and neck

KW - head and neck carcinoma

KW - immunopathology

KW - keratin 17

UR - https://www.scopus.com/pages/publications/85044927644

U2 - 10.1002/hed.25164

DO - 10.1002/hed.25164

M3 - Article

C2 - 29626364

AN - SCOPUS:85044927644

SN - 1043-3074

VL - 40

SP - 1788

EP - 1798

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival

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