Escherichia coli xth mutants are hypersensitive to hydrogen peroxide

B. Demple; J. Halbrook; S. Linn

Escherichia coli xth mutants are hypersensitive to hydrogen peroxide

B. Demple
, J. Halbrook
, S. Linn

Pharmacological Sciences

University of California at Berkeley

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

E. coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H₂O₂ at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth^- E. coli and should aid in clarifying peroxide-inducing lethality and the in vivo role of exonuclease III.

Original language	English
Pages (from-to)	1079-1082
Number of pages	4
Journal	Journal of Bacteriology
Volume	153
Issue number	2
State	Published - 1983

Cite this

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title = "Escherichia coli xth mutants are hypersensitive to hydrogen peroxide",

abstract = "E. coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-inducing lethality and the in vivo role of exonuclease III.",

author = "B. Demple and J. Halbrook and S. Linn",

year = "1983",

language = "English",

volume = "153",

pages = "1079--1082",

journal = "Journal of Bacteriology",

issn = "0021-9193",

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T1 - Escherichia coli xth mutants are hypersensitive to hydrogen peroxide

AU - Demple, B.

AU - Halbrook, J.

AU - Linn, S.

PY - 1983

Y1 - 1983

N2 - E. coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-inducing lethality and the in vivo role of exonuclease III.

AB - E. coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-inducing lethality and the in vivo role of exonuclease III.

UR - https://www.scopus.com/pages/publications/0020693158

M3 - Article

C2 - 6337115

AN - SCOPUS:0020693158

SN - 0021-9193

VL - 153

SP - 1079

EP - 1082

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 2

ER -

Escherichia coli xth mutants are hypersensitive to hydrogen peroxide

Abstract

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