Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Sabine Rohrmann; Jakob Linseisen; Hendriek C. Boshuizen; John Whittaker; Antonio Agudo; Paolo Vineis; Paolo Boffetta; Majken K. Jensen; Anja Olsen; Kim Overvad; Anne Tjønneland; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Manuela M. Bergmann; Heiner Boeing; Naomi Allen; Tim Key; Sheila Bingham; Kay Tee Khaw; Georgia Kyriazi; Stavroula Soukara; Antonia Trichopoulou; Salvatore Panico; Domenico Palli; Sabina Sieri; Rosario Tumino; Petra H.M. Peeters; H. Bas Bueno-De-Mesquita; Frederike L. Büchner; Inger Torhild Gram; Eiliv Lund; Eva Ardanaz; María Dolores Chirlaque; Miren Dorronsoro; Maria José Sánchez Pérez; Jose R. Quirós; Göran Berglund; Lars Janzon; Torgny Rasmuson; Lars Weinehall; Pietro Ferrari; Mazda Jenab; Teresa Norat; Elio Riboli

doi:10.1093/aje/kwj326

Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Sabine Rohrmann
, Jakob Linseisen
, Hendriek C. Boshuizen
, John Whittaker
, Antonio Agudo
, Paolo Vineis
, Paolo Boffetta
, Majken K. Jensen
, Anja Olsen
, Kim Overvad
, Anne Tjønneland
, Marie Christine Boutron-Ruault
, Françoise Clavel-Chapelon
, Manuela M. Bergmann
, Heiner Boeing
, Naomi Allen
, Tim Key
, Sheila Bingham
, Kay Tee Khaw
, Georgia Kyriazi

Stavroula Soukara, Antonia Trichopoulou, Salvatore Panico, Domenico Palli, Sabina Sieri, Rosario Tumino, Petra H.M. Peeters, H. Bas Bueno-De-Mesquita, Frederike L. Büchner, Inger Torhild Gram, Eiliv Lund, Eva Ardanaz, María Dolores Chirlaque, Miren Dorronsoro, Maria José Sánchez Pérez, Jose R. Quirós, Göran Berglund, Lars Janzon, Torgny Rasmuson, Lars Weinehall, Pietro Ferrari, Mazda Jenab, Teresa Norat, Elio Riboli

German Cancer Research Center
National Institute of Public Health and the Environment
London School of Hygiene and Tropical Medicine
Institute Catala Oncologia
Imperial College London
Aalborg University
Danish Cancer Society
University of Paris Sud
German Institute of Human Nutrition Potsdam-Rehbruecke
University of Oxford
University of Cambridge
National and Kapodistrian University of Athens
University of Naples Federico II
Centro Per Lo Studio E La Prevenzione Oncologica
IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
Azienda Ospedaliera Civile M.P. Arezzo
Utrecht University
University of Tromsø – The Arctic University of Norway
Instituto de Salud Publica, Pamplona
IMIB-Arrixaca
Public Health Division of Gipuzkoa
Escuela Andaluza de Salud Publica
Public Health and Health Planning Directorate
Lund University
Umeå University
International Agency for Research on Cancer

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (≥60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.

Original language	English
Pages (from-to)	1103-1114
Number of pages	12
Journal	American Journal of Epidemiology
Volume	164
Issue number	11
DOIs	https://doi.org/10.1093/aje/kwj326
State	Published - Dec 2006

Keywords

Alcohol drinking
Cohort studies
Ethanol
Lung neoplasms

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Rohrmann, S., Linseisen, J., Boshuizen, H. C., Whittaker, J., Agudo, A., Vineis, P., Boffetta, P., Jensen, M. K., Olsen, A., Overvad, K., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Bergmann, M. M., Boeing, H., Allen, N., Key, T., Bingham, S., Khaw, K. T., ... Riboli, E. (2006). Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). American Journal of Epidemiology, 164(11), 1103-1114. https://doi.org/10.1093/aje/kwj326

@article{d799f18a7df74e5ea9162f94d6156472,

title = "Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)",

abstract = "Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95\% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95\% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95\% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (≥60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95\% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.",

keywords = "Alcohol drinking, Cohort studies, Ethanol, Lung neoplasms",

author = "Sabine Rohrmann and Jakob Linseisen and Boshuizen, \{Hendriek C.\} and John Whittaker and Antonio Agudo and Paolo Vineis and Paolo Boffetta and Jensen, \{Majken K.\} and Anja Olsen and Kim Overvad and Anne Tj{\o}nneland and Boutron-Ruault, \{Marie Christine\} and Fran{\c c}oise Clavel-Chapelon and Bergmann, \{Manuela M.\} and Heiner Boeing and Naomi Allen and Tim Key and Sheila Bingham and Khaw, \{Kay Tee\} and Georgia Kyriazi and Stavroula Soukara and Antonia Trichopoulou and Salvatore Panico and Domenico Palli and Sabina Sieri and Rosario Tumino and Peeters, \{Petra H.M.\} and Bueno-De-Mesquita, \{H. Bas\} and B{\"u}chner, \{Frederike L.\} and Gram, \{Inger Torhild\} and Eiliv Lund and Eva Ardanaz and Chirlaque, \{Mar{\'i}a Dolores\} and Miren Dorronsoro and P{\'e}rez, \{Maria Jos{\'e} S{\'a}nchez\} and Quir{\'o}s, \{Jose R.\} and G{\"o}ran Berglund and Lars Janzon and Torgny Rasmuson and Lars Weinehall and Pietro Ferrari and Mazda Jenab and Teresa Norat and Elio Riboli",

year = "2006",

month = dec,

doi = "10.1093/aje/kwj326",

language = "English",

volume = "164",

pages = "1103--1114",

journal = "American Journal of Epidemiology",

issn = "0002-9262",

number = "11",

}

Rohrmann, S, Linseisen, J, Boshuizen, HC, Whittaker, J, Agudo, A, Vineis, P, Boffetta, P, Jensen, MK, Olsen, A, Overvad, K, Tjønneland, A, Boutron-Ruault, MC, Clavel-Chapelon, F, Bergmann, MM, Boeing, H, Allen, N, Key, T, Bingham, S, Khaw, KT, Kyriazi, G, Soukara, S, Trichopoulou, A, Panico, S, Palli, D, Sieri, S, Tumino, R, Peeters, PHM, Bueno-De-Mesquita, HB, Büchner, FL, Gram, IT, Lund, E, Ardanaz, E, Chirlaque, MD, Dorronsoro, M, Pérez, MJS, Quirós, JR, Berglund, G, Janzon, L, Rasmuson, T, Weinehall, L, Ferrari, P, Jenab, M, Norat, T & Riboli, E 2006, 'Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)', American Journal of Epidemiology, vol. 164, no. 11, pp. 1103-1114. https://doi.org/10.1093/aje/kwj326

TY - JOUR

T1 - Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Rohrmann, Sabine

AU - Linseisen, Jakob

AU - Boshuizen, Hendriek C.

AU - Whittaker, John

AU - Agudo, Antonio

AU - Vineis, Paolo

AU - Boffetta, Paolo

AU - Jensen, Majken K.

AU - Olsen, Anja

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Bergmann, Manuela M.

AU - Boeing, Heiner

AU - Allen, Naomi

AU - Key, Tim

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Kyriazi, Georgia

AU - Soukara, Stavroula

AU - Trichopoulou, Antonia

AU - Panico, Salvatore

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Peeters, Petra H.M.

AU - Bueno-De-Mesquita, H. Bas

AU - Büchner, Frederike L.

AU - Gram, Inger Torhild

AU - Lund, Eiliv

AU - Ardanaz, Eva

AU - Chirlaque, María Dolores

AU - Dorronsoro, Miren

AU - Pérez, Maria José Sánchez

AU - Quirós, Jose R.

AU - Berglund, Göran

AU - Janzon, Lars

AU - Rasmuson, Torgny

AU - Weinehall, Lars

AU - Ferrari, Pietro

AU - Jenab, Mazda

AU - Norat, Teresa

AU - Riboli, Elio

PY - 2006/12

Y1 - 2006/12

N2 - Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (≥60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.

AB - Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (≥60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.

KW - Alcohol drinking

KW - Cohort studies

KW - Ethanol

KW - Lung neoplasms

UR - https://www.scopus.com/pages/publications/33845193649

U2 - 10.1093/aje/kwj326

DO - 10.1093/aje/kwj326

M3 - Article

C2 - 16987924

AN - SCOPUS:33845193649

SN - 0002-9262

VL - 164

SP - 1103

EP - 1114

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 11

ER -

Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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Keywords

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