Examining phenotype differences in mouse placenta with volume rendering and segmentation

Richard Sharp; Randall Ridgway; Kishore Mosaliganti; Okan Irfanoglu; Pamela Wenzel; Raghu Machiraju; Alain De Bruin; Gustavo Leone; Tony Pan; Kun Huang; Joel Saltz

doi:10.1109/LSSA.2006.250431

Examining phenotype differences in mouse placenta with volume rendering and segmentation

Richard Sharp
, Randall Ridgway
, Kishore Mosaliganti
, Okan Irfanoglu
, Pamela Wenzel
, Raghu Machiraju
, Alain De Bruin
, Gustavo Leone
, Tony Pan
, Kun Huang
, Joel Saltz

Biomedical Informatics

Ohio State University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

We present an application problem of examining phenotype differences in wildtype and retinoblastoma (Rb) knockout specimens of mouse placenta. The lack of the Rb gene causes uncontrolled tissue growth which forces infiltrations into critical sections of mouse placenta that lead to fetal death. We briefly describe our method for volume visualization of mouse placenta tissue level intermixing at a microscopic scale for both wildtype and Rb knockout types. Our technique combines non-trivial registration techniques, an N-point correlation classifier, and a volume rendering step. Our final volume renderings show tissue intermixing differences between both wildtype and Rb knockout specimens that are not obvious from examining the two dimensional image stack alone.

Original language	English
Title of host publication	2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
DOIs	https://doi.org/10.1109/LSSA.2006.250431
State	Published - 2006
Event	2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 - Bethesda, MD, United States Duration: Jul 13 2006 → Jul 14 2006

Publication series

Name	2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006

Conference

Conference	2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
Country/Territory	United States
City	Bethesda, MD
Period	07/13/06 → 07/14/06

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10.1109/LSSA.2006.250431

Cite this

Sharp, R., Ridgway, R., Mosaliganti, K., Irfanoglu, O., Wenzel, P., Machiraju, R., De Bruin, A., Leone, G., Pan, T., Huang, K., & Saltz, J. (2006). Examining phenotype differences in mouse placenta with volume rendering and segmentation. In 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 Article 4015832 (2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006). https://doi.org/10.1109/LSSA.2006.250431

@inproceedings{9d26998ea94c4dafa498e3d48f6d512d,

title = "Examining phenotype differences in mouse placenta with volume rendering and segmentation",

abstract = "We present an application problem of examining phenotype differences in wildtype and retinoblastoma (Rb) knockout specimens of mouse placenta. The lack of the Rb gene causes uncontrolled tissue growth which forces infiltrations into critical sections of mouse placenta that lead to fetal death. We briefly describe our method for volume visualization of mouse placenta tissue level intermixing at a microscopic scale for both wildtype and Rb knockout types. Our technique combines non-trivial registration techniques, an N-point correlation classifier, and a volume rendering step. Our final volume renderings show tissue intermixing differences between both wildtype and Rb knockout specimens that are not obvious from examining the two dimensional image stack alone.",

author = "Richard Sharp and Randall Ridgway and Kishore Mosaliganti and Okan Irfanoglu and Pamela Wenzel and Raghu Machiraju and \{De Bruin\}, Alain and Gustavo Leone and Tony Pan and Kun Huang and Joel Saltz",

year = "2006",

doi = "10.1109/LSSA.2006.250431",

language = "English",

isbn = "1424402786",

series = "2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006",

booktitle = "2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006",

note = "2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 ; Conference date: 13-07-2006 Through 14-07-2006",

}

Sharp, R, Ridgway, R, Mosaliganti, K, Irfanoglu, O, Wenzel, P, Machiraju, R, De Bruin, A, Leone, G, Pan, T, Huang, K & Saltz, J 2006, Examining phenotype differences in mouse placenta with volume rendering and segmentation. in 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006., 4015832, 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006, 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006, Bethesda, MD, United States, 07/13/06. https://doi.org/10.1109/LSSA.2006.250431

Examining phenotype differences in mouse placenta with volume rendering and segmentation. / Sharp, Richard; Ridgway, Randall; Mosaliganti, Kishore et al.
2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006. 2006. 4015832 (2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Examining phenotype differences in mouse placenta with volume rendering and segmentation

AU - Sharp, Richard

AU - Ridgway, Randall

AU - Mosaliganti, Kishore

AU - Irfanoglu, Okan

AU - Wenzel, Pamela

AU - Machiraju, Raghu

AU - De Bruin, Alain

AU - Leone, Gustavo

AU - Pan, Tony

AU - Huang, Kun

AU - Saltz, Joel

PY - 2006

Y1 - 2006

N2 - We present an application problem of examining phenotype differences in wildtype and retinoblastoma (Rb) knockout specimens of mouse placenta. The lack of the Rb gene causes uncontrolled tissue growth which forces infiltrations into critical sections of mouse placenta that lead to fetal death. We briefly describe our method for volume visualization of mouse placenta tissue level intermixing at a microscopic scale for both wildtype and Rb knockout types. Our technique combines non-trivial registration techniques, an N-point correlation classifier, and a volume rendering step. Our final volume renderings show tissue intermixing differences between both wildtype and Rb knockout specimens that are not obvious from examining the two dimensional image stack alone.

AB - We present an application problem of examining phenotype differences in wildtype and retinoblastoma (Rb) knockout specimens of mouse placenta. The lack of the Rb gene causes uncontrolled tissue growth which forces infiltrations into critical sections of mouse placenta that lead to fetal death. We briefly describe our method for volume visualization of mouse placenta tissue level intermixing at a microscopic scale for both wildtype and Rb knockout types. Our technique combines non-trivial registration techniques, an N-point correlation classifier, and a volume rendering step. Our final volume renderings show tissue intermixing differences between both wildtype and Rb knockout specimens that are not obvious from examining the two dimensional image stack alone.

UR - https://www.scopus.com/pages/publications/42749106207

U2 - 10.1109/LSSA.2006.250431

DO - 10.1109/LSSA.2006.250431

M3 - Conference contribution

AN - SCOPUS:42749106207

SN - 1424402786

SN - 9781424402786

T3 - 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006

BT - 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006

T2 - 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006

Y2 - 13 July 2006 through 14 July 2006

ER -

Examining phenotype differences in mouse placenta with volume rendering and segmentation

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