Exploring the manifestations of anxiety in children with autism spectrum disorders

Victoria Hallett; Luc Lecavalier; Denis G. Sukhodolsky; Noreen Cipriano; Michael G. Aman; James T. McCracken; Christopher J. McDougle; Elaine Tierney; Bryan H. King; Eric Hollander; Linmarie Sikich; Joel Bregman; Evdokia Anagnostou; Craig Donnelly; Lily Katsovich; Kimberly Dukes; Benedetto Vitiello; Kenneth Gadow; Lawrence Scahill

doi:10.1007/s10803-013-1775-1

Exploring the manifestations of anxiety in children with autism spectrum disorders

Victoria Hallett
, Luc Lecavalier
, Denis G. Sukhodolsky
, Noreen Cipriano
, Michael G. Aman
, James T. McCracken
, Christopher J. McDougle
, Elaine Tierney
, Bryan H. King
, Eric Hollander
, Linmarie Sikich
, Joel Bregman
, Evdokia Anagnostou
, Craig Donnelly
, Lily Katsovich
, Kimberly Dukes
, Benedetto Vitiello
, Kenneth Gadow
, Lawrence Scahill

Psychiatry

Yale University
King's College London
Ohio State University
University of California at Los Angeles
Massachusetts General Hospital
Kennedy Krieger Institute
University of Washington
Albert Einstein College of Medicine
University of North Carolina at Chapel Hill
Center for Autism
University of Toronto
Dartmouth College
DM-STAT Inc
Boston University
National Institutes of Health
Emory University

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement.

Original language	English
Pages (from-to)	2341-2352
Number of pages	12
Journal	Journal of Autism and Developmental Disorders
Volume	43
Issue number	10
DOIs	https://doi.org/10.1007/s10803-013-1775-1
State	Published - Oct 2013

Keywords

Anxiety
Autism spectrum disorders
Clinical Trials
Measurement

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10.1007/s10803-013-1775-1

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Hallett, V., Lecavalier, L., Sukhodolsky, D. G., Cipriano, N., Aman, M. G., McCracken, J. T., McDougle, C. J., Tierney, E., King, B. H., Hollander, E., Sikich, L., Bregman, J., Anagnostou, E., Donnelly, C., Katsovich, L., Dukes, K., Vitiello, B., Gadow, K., & Scahill, L. (2013). Exploring the manifestations of anxiety in children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(10), 2341-2352. https://doi.org/10.1007/s10803-013-1775-1

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title = "Exploring the manifestations of anxiety in children with autism spectrum disorders",

abstract = "This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement.",

keywords = "Anxiety, Autism spectrum disorders, Clinical Trials, Measurement",

author = "Victoria Hallett and Luc Lecavalier and Sukhodolsky, \{Denis G.\} and Noreen Cipriano and Aman, \{Michael G.\} and McCracken, \{James T.\} and McDougle, \{Christopher J.\} and Elaine Tierney and King, \{Bryan H.\} and Eric Hollander and Linmarie Sikich and Joel Bregman and Evdokia Anagnostou and Craig Donnelly and Lily Katsovich and Kimberly Dukes and Benedetto Vitiello and Kenneth Gadow and Lawrence Scahill",

year = "2013",

month = oct,

doi = "10.1007/s10803-013-1775-1",

language = "English",

volume = "43",

pages = "2341--2352",

journal = "Journal of Autism and Developmental Disorders",

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Hallett, V, Lecavalier, L, Sukhodolsky, DG, Cipriano, N, Aman, MG, McCracken, JT, McDougle, CJ, Tierney, E, King, BH, Hollander, E, Sikich, L, Bregman, J, Anagnostou, E, Donnelly, C, Katsovich, L, Dukes, K, Vitiello, B, Gadow, K & Scahill, L 2013, 'Exploring the manifestations of anxiety in children with autism spectrum disorders', Journal of Autism and Developmental Disorders, vol. 43, no. 10, pp. 2341-2352. https://doi.org/10.1007/s10803-013-1775-1

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AU - Aman, Michael G.

AU - McCracken, James T.

AU - McDougle, Christopher J.

AU - Tierney, Elaine

AU - King, Bryan H.

AU - Hollander, Eric

AU - Sikich, Linmarie

AU - Bregman, Joel

AU - Anagnostou, Evdokia

AU - Donnelly, Craig

AU - Katsovich, Lily

AU - Dukes, Kimberly

AU - Vitiello, Benedetto

AU - Gadow, Kenneth

AU - Scahill, Lawrence

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KW - Clinical Trials

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Exploring the manifestations of anxiety in children with autism spectrum disorders

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