Factors Influencing Outcome of Kidney Allografts From Pretreated Cadaveric Donors

Sylvester Sterioff; Horst Zincke; Wayne C. Waltzer; S. Breanndan Moore; Peter P. Frohnert; Kenneth P. Offord

doi:10.1001/archsurg.1981.01380130049011

Factors Influencing Outcome of Kidney Allografts From Pretreated Cadaveric Donors

Sylvester Sterioff
, Horst Zincke
, Wayne C. Waltzer
, S. Breanndan Moore
, Peter P. Frohnert
, Kenneth P. Offord

Urology

Mayo Clinic Rochester, MN

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A five-year retrospective analysis of patient and graft survival after initial cadaveric kidney transplantation showed that recipients of kidneys from cadaveric donors pretreated with cyclophosphamide (Cytoxan) and methylprednisolone (Medrol) had better graft survival than those patients who received nonpretreated kidneys. In patients not receiving transfusions, transplantation of a pretreated kidney improved the chances of success, with graft survival equivalent to that for patients receiving transfusions. Splenectomy was beneficial for graft survival and did not affect overall patient survival. The effect of splenectomy could not be clearly separated from the effect of donor pretreatment.

Original language	English
Pages (from-to)	73-77
Number of pages	5
Journal	Archives of Surgery
Volume	116
Issue number	1
DOIs	https://doi.org/10.1001/archsurg.1981.01380130049011
State	Published - Jan 1981

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title = "Factors Influencing Outcome of Kidney Allografts From Pretreated Cadaveric Donors",

abstract = "A five-year retrospective analysis of patient and graft survival after initial cadaveric kidney transplantation showed that recipients of kidneys from cadaveric donors pretreated with cyclophosphamide (Cytoxan) and methylprednisolone (Medrol) had better graft survival than those patients who received nonpretreated kidneys. In patients not receiving transfusions, transplantation of a pretreated kidney improved the chances of success, with graft survival equivalent to that for patients receiving transfusions. Splenectomy was beneficial for graft survival and did not affect overall patient survival. The effect of splenectomy could not be clearly separated from the effect of donor pretreatment.",

author = "Sylvester Sterioff and Horst Zincke and Waltzer, \{Wayne C.\} and Moore, \{S. Breanndan\} and Frohnert, \{Peter P.\} and Offord, \{Kenneth P.\}",

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AU - Sterioff, Sylvester

AU - Zincke, Horst

AU - Waltzer, Wayne C.

AU - Moore, S. Breanndan

AU - Frohnert, Peter P.

AU - Offord, Kenneth P.

PY - 1981/1

Y1 - 1981/1

N2 - A five-year retrospective analysis of patient and graft survival after initial cadaveric kidney transplantation showed that recipients of kidneys from cadaveric donors pretreated with cyclophosphamide (Cytoxan) and methylprednisolone (Medrol) had better graft survival than those patients who received nonpretreated kidneys. In patients not receiving transfusions, transplantation of a pretreated kidney improved the chances of success, with graft survival equivalent to that for patients receiving transfusions. Splenectomy was beneficial for graft survival and did not affect overall patient survival. The effect of splenectomy could not be clearly separated from the effect of donor pretreatment.

AB - A five-year retrospective analysis of patient and graft survival after initial cadaveric kidney transplantation showed that recipients of kidneys from cadaveric donors pretreated with cyclophosphamide (Cytoxan) and methylprednisolone (Medrol) had better graft survival than those patients who received nonpretreated kidneys. In patients not receiving transfusions, transplantation of a pretreated kidney improved the chances of success, with graft survival equivalent to that for patients receiving transfusions. Splenectomy was beneficial for graft survival and did not affect overall patient survival. The effect of splenectomy could not be clearly separated from the effect of donor pretreatment.

UR - https://www.scopus.com/pages/publications/0019394097

U2 - 10.1001/archsurg.1981.01380130049011

DO - 10.1001/archsurg.1981.01380130049011

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SN - 0004-0010

VL - 116

SP - 73

EP - 77

JO - Archives of Surgery

JF - Archives of Surgery

IS - 1

ER -

Factors Influencing Outcome of Kidney Allografts From Pretreated Cadaveric Donors

Abstract

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