Flow induced platelet activation in mechanical heart valves - in vitro studies

Wei Yin; Danny Bluestein; Jolyon Jesty; Peter Perrotta

Flow induced platelet activation in mechanical heart valves - in vitro studies

Wei Yin
, Danny Bluestein
, Jolyon Jesty
, Peter Perrotta

Biomedical Engineering

Stony Brook University

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Thromboembolism is a common complication of mechanical heart valves (MHV). The objective of this study was to elucidate mechanisms of thromboembolism in flow past MHV in vitro. Gel-filtered platelets were recirculated through the MHV mounted in a model of left ventricular assist device (LVAD) and their activation was measured by using an innovative platelet activity state (PAS) assay. The motion of one MHV in LVAD was restricted by suture, and LVAD with free MHV was considered as control. The platelet activation increased as a function of the recirculation time past the valve, and restricted valve had a higher activation rate as compared to controls. Flow cytometry was conducted to compare the results obtained from PAS assay.

Original language	English
Pages (from-to)	1599-1600
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	2
State	Published - 2002
Event	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002

Keywords

Flow cytometry
Left ventricular assist device
Mechanical heart valve
Platelet activity state
Thromboembolism

Cite this

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title = "Flow induced platelet activation in mechanical heart valves - in vitro studies",

abstract = "Thromboembolism is a common complication of mechanical heart valves (MHV). The objective of this study was to elucidate mechanisms of thromboembolism in flow past MHV in vitro. Gel-filtered platelets were recirculated through the MHV mounted in a model of left ventricular assist device (LVAD) and their activation was measured by using an innovative platelet activity state (PAS) assay. The motion of one MHV in LVAD was restricted by suture, and LVAD with free MHV was considered as control. The platelet activation increased as a function of the recirculation time past the valve, and restricted valve had a higher activation rate as compared to controls. Flow cytometry was conducted to compare the results obtained from PAS assay.",

keywords = "Flow cytometry, Left ventricular assist device, Mechanical heart valve, Platelet activity state, Thromboembolism",

author = "Wei Yin and Danny Bluestein and Jolyon Jesty and Peter Perrotta",

year = "2002",

language = "English",

volume = "2",

pages = "1599--1600",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

note = "Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) ; Conference date: 23-10-2002 Through 26-10-2002",

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TY - JOUR

T1 - Flow induced platelet activation in mechanical heart valves - in vitro studies

AU - Yin, Wei

AU - Bluestein, Danny

AU - Jesty, Jolyon

AU - Perrotta, Peter

PY - 2002

Y1 - 2002

N2 - Thromboembolism is a common complication of mechanical heart valves (MHV). The objective of this study was to elucidate mechanisms of thromboembolism in flow past MHV in vitro. Gel-filtered platelets were recirculated through the MHV mounted in a model of left ventricular assist device (LVAD) and their activation was measured by using an innovative platelet activity state (PAS) assay. The motion of one MHV in LVAD was restricted by suture, and LVAD with free MHV was considered as control. The platelet activation increased as a function of the recirculation time past the valve, and restricted valve had a higher activation rate as compared to controls. Flow cytometry was conducted to compare the results obtained from PAS assay.

AB - Thromboembolism is a common complication of mechanical heart valves (MHV). The objective of this study was to elucidate mechanisms of thromboembolism in flow past MHV in vitro. Gel-filtered platelets were recirculated through the MHV mounted in a model of left ventricular assist device (LVAD) and their activation was measured by using an innovative platelet activity state (PAS) assay. The motion of one MHV in LVAD was restricted by suture, and LVAD with free MHV was considered as control. The platelet activation increased as a function of the recirculation time past the valve, and restricted valve had a higher activation rate as compared to controls. Flow cytometry was conducted to compare the results obtained from PAS assay.

KW - Flow cytometry

KW - Left ventricular assist device

KW - Mechanical heart valve

KW - Platelet activity state

KW - Thromboembolism

UR - https://www.scopus.com/pages/publications/0036911243

M3 - Conference article

AN - SCOPUS:0036911243

SN - 0589-1019

VL - 2

SP - 1599

EP - 1600

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

T2 - Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)

Y2 - 23 October 2002 through 26 October 2002

ER -

Flow induced platelet activation in mechanical heart valves - in vitro studies

Abstract

Keywords

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