TY - JOUR
T1 - Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Ros, Martine M.
AU - Bas Bueno-De-Mesquita, H. B.
AU - Büchner, Frederike L.
AU - Aben, Katja K.H.
AU - Kampman, Ellen
AU - Egevad, Lars
AU - Overvad, Kim
AU - Tjãnneland, Anne
AU - Roswall, Nina
AU - Clavel-Chapelon, Francoise
AU - Kaaks, Rudolf
AU - Chang-Claude, Jenny
AU - Boeing, Heiner
AU - Weikert, Steffen
AU - Trichopoulou, Antonia
AU - Orfanos, Philippos
AU - Stasinopulou, Georgia
AU - Saieva, Calogero
AU - Krogh, Vittorio
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Mattiello, Amalia
AU - Peeters, Petra H.M.
AU - Van Duijnhoven, Fränzel J.B.
AU - Lund, Eiliv
AU - Gram, Inger T.
AU - Chirlaque, Maria D.
AU - Barricarte, Aurelio
AU - Rodríguez, Laudina
AU - Molina, Esther
AU - Gonzalez, Carlos
AU - Dorronsoro, Miren
AU - Manjer, Jonas
AU - Ehrnström, Roy
AU - Ljungberg, Börje
AU - Allen, Naomi E.
AU - Roddam, Andrew W.
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Boffetta, Paolo
AU - Slimani, Nadia
AU - Michaud, Dominique S.
AU - Kiemeney, Lambertus A.L.M.
AU - Riboli, Elio
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95%CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95%CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95%CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.
AB - Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95%CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95%CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95%CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.
KW - bladder cancer
KW - EPIC
KW - fluid
KW - urothelial cell carcinomas
UR - https://www.scopus.com/pages/publications/79953309327
U2 - 10.1002/ijc.25592
DO - 10.1002/ijc.25592
M3 - Article
C2 - 20715171
AN - SCOPUS:79953309327
SN - 0020-7136
VL - 128
SP - 2695
EP - 2708
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 11
ER -