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Fluoro-Taxoid Anticancer Agents

  • Antonella Pepe
  • , Larisa Kuznetsova
  • , Liang Sun
  • , Iwao Ojima
  • University of Minnesota Twin Cities
  • Brookhaven National Laboratory
  • Stony Brook University

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

13 Scopus citations
Original languageEnglish
Title of host publicationFluorine in Medicinal Chemistry and Chemical Biology
PublisherJohn Wiley & Sons, Ltd.
Pages117-139
Number of pages23
ISBN (Print)9781405167208
DOIs
StatePublished - Apr 21 2009

Keywords

  • Fluoro-taxoid anticancer agents
  • Importance of fluorine in bioorganic and medicinal chemistry
  • Paclitaxel (Taxol®) and its semisynthetic analogue docetaxel
  • Paclitaxel, taxoids, and second-generation taxoids
  • Possible bioactive conformations of fluoro-taxoids
  • Second-generation Taxoids and C-seco-taxoids with strategic incorporation of fluorine
  • Synthesis and biological evaluation of C-2-(3- Fluorobenzoyl)-C-seco-taxoids
  • Synthesis and biological evaluation of C-3-difluorovinyl-taxoids

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