Focal cerebral ischaemia in the rat: Neuropathology, local cerebral blood flow and cerebrovascular permeability

G. Teasdale; G. Tyson; A. Tamura; D. I. Graham; J. McCulloch

Focal cerebral ischaemia in the rat: Neuropathology, local cerebral blood flow and cerebrovascular permeability

G. Teasdale
, G. Tyson
, A. Tamura
, D. I. Graham
, J. McCulloch

Office of the Dean of Medicine

NHS Greater Glasgow and Clyde
University of Glasgow

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Focal cerebral ischaemia has been produced in the rat by occlusion of the middle cerebral artery. The area of ischaemic damage involves the cortex and neostriatum and can be identified in perfusion fixed and paraffin embedded material and also in frozen sections. Quantitative autoradiographic studies show striking alterations in the distribution of local cerebral blood flow, which correlate closely with histological changes. Blood brain barrier permeability to αAIB is unaltered within the first 4 hrs, unless an additional insult in the form of halothane induced hypotension is introduced.

Original language	English
Pages (from-to)	83-97
Number of pages	15
Journal	Advances in the Biosciences
Volume	43
Issue number	C
State	Published - 1983

Keywords

Blood-brain-barrier
Focal Cerebral Ischaemia
Neuropathology
Quantitative Autoradiography Cerebral Blood Flow
Rat

Cite this

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abstract = "Focal cerebral ischaemia has been produced in the rat by occlusion of the middle cerebral artery. The area of ischaemic damage involves the cortex and neostriatum and can be identified in perfusion fixed and paraffin embedded material and also in frozen sections. Quantitative autoradiographic studies show striking alterations in the distribution of local cerebral blood flow, which correlate closely with histological changes. Blood brain barrier permeability to αAIB is unaltered within the first 4 hrs, unless an additional insult in the form of halothane induced hypotension is introduced.",

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T2 - Neuropathology, local cerebral blood flow and cerebrovascular permeability

AU - Teasdale, G.

AU - Tyson, G.

AU - Tamura, A.

AU - Graham, D. I.

AU - McCulloch, J.

PY - 1983

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N2 - Focal cerebral ischaemia has been produced in the rat by occlusion of the middle cerebral artery. The area of ischaemic damage involves the cortex and neostriatum and can be identified in perfusion fixed and paraffin embedded material and also in frozen sections. Quantitative autoradiographic studies show striking alterations in the distribution of local cerebral blood flow, which correlate closely with histological changes. Blood brain barrier permeability to αAIB is unaltered within the first 4 hrs, unless an additional insult in the form of halothane induced hypotension is introduced.

AB - Focal cerebral ischaemia has been produced in the rat by occlusion of the middle cerebral artery. The area of ischaemic damage involves the cortex and neostriatum and can be identified in perfusion fixed and paraffin embedded material and also in frozen sections. Quantitative autoradiographic studies show striking alterations in the distribution of local cerebral blood flow, which correlate closely with histological changes. Blood brain barrier permeability to αAIB is unaltered within the first 4 hrs, unless an additional insult in the form of halothane induced hypotension is introduced.

KW - Blood-brain-barrier

KW - Focal Cerebral Ischaemia

KW - Neuropathology

KW - Quantitative Autoradiography Cerebral Blood Flow

KW - Rat

UR - https://www.scopus.com/pages/publications/49049122844

M3 - Article

AN - SCOPUS:49049122844

SN - 0065-3446

VL - 43

SP - 83

EP - 97

JO - Advances in the Biosciences

JF - Advances in the Biosciences

IS - C

ER -

Focal cerebral ischaemia in the rat: Neuropathology, local cerebral blood flow and cerebrovascular permeability

Abstract

Keywords

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