GABPβ1L Wakes Up TERT

Gilbert J. Rahme; Elizabeth Gaskell; Bradley E. Bernstein

doi:10.1016/j.ccell.2018.08.011

GABPβ1L Wakes Up TERT

Gilbert J. Rahme
, Elizabeth Gaskell
, Bradley E. Bernstein

Massachusetts General Hospital
Broad Institute

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target. TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target.

Original language	English
Pages (from-to)	358-360
Number of pages	3
Journal	Cancer Cell
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.ccell.2018.08.011
State	Published - Sep 10 2018

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title = "GABPβ1L Wakes Up TERT",

abstract = "TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target. TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target.",

author = "Rahme, \{Gilbert J.\} and Elizabeth Gaskell and Bernstein, \{Bradley E.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = sep,

day = "10",

doi = "10.1016/j.ccell.2018.08.011",

language = "English",

volume = "34",

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journal = "Cancer Cell",

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T1 - GABPβ1L Wakes Up TERT

AU - Rahme, Gilbert J.

AU - Gaskell, Elizabeth

AU - Bernstein, Bradley E.

PY - 2018/9/10

Y1 - 2018/9/10

N2 - TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target. TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target.

AB - TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target. TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target.

UR - https://www.scopus.com/pages/publications/85052729168

U2 - 10.1016/j.ccell.2018.08.011

DO - 10.1016/j.ccell.2018.08.011

M3 - Short survey

C2 - 30205042

AN - SCOPUS:85052729168

SN - 1535-6108

VL - 34

SP - 358

EP - 360

JO - Cancer Cell

JF - Cancer Cell

IS - 3

ER -

GABPβ1L Wakes Up TERT

Abstract

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