Gemcitabine associated retinopathy and nephropathy

Purpose: To report a case of presumed gemcitabine-induced retinopathy and nephropathy. Methods: Case Report. Retrospective chart review. Results: A 64-year-old woman with a recent diagnosis of metastatic cholangiocarcinoma presented with progressive visual loss and renal failure shortly after the initiation of a chemotherapy regimen which included gemcitabine. Clinical examination and fluorescein angiography showed findings of severe retinal ischemia. Conclusion: Although gemcitabine chemotherapy has been reported to cause a Purtscherlike retinopathy, we propose in our patient a gemcitabine-induced vasculopathy that lead to significant retinal and renal ischemia.