TY - JOUR
T1 - Genetically Determined Height and Risk of Non-hodgkin Lymphoma
AU - Moore, Amy
AU - Kane, Eleanor
AU - Wang, Zhaoming
AU - Panagiotou, Orestis A.
AU - Teras, Lauren R.
AU - Monnereau, Alain
AU - Wong Doo, Nicole
AU - Machiela, Mitchell J.
AU - Skibola, Christine F.
AU - Slager, Susan L.
AU - Salles, Gilles
AU - Camp, Nicola J.
AU - Bracci, Paige M.
AU - Nieters, Alexandra
AU - Vermeulen, Roel C.H.
AU - Vijai, Joseph
AU - Smedby, Karin E.
AU - Zhang, Yawei
AU - Vajdic, Claire M.
AU - Cozen, Wendy
AU - Spinelli, John J.
AU - Hjalgrim, Henrik
AU - Giles, Graham G.
AU - Link, Brian K.
AU - Clavel, Jacqueline
AU - Arslan, Alan A.
AU - Purdue, Mark P.
AU - Tinker, Lesley F.
AU - Albanes, Demetrius
AU - Ferri, Giovanni M.
AU - Habermann, Thomas M.
AU - Adami, Hans Olov
AU - Becker, Nikolaus
AU - Benavente, Yolanda
AU - Bisanzi, Simonetta
AU - Boffetta, Paolo
AU - Brennan, Paul
AU - Brooks-Wilson, Angela R.
AU - Canzian, Federico
AU - Conde, Lucia
AU - Cox, David G.
AU - Curtin, Karen
AU - Foretova, Lenka
AU - Gapstur, Susan M.
AU - Ghesquières, Hervé
AU - Glenn, Martha
AU - Glimelius, Bengt
AU - Jackson, Rebecca D.
AU - Lan, Qing
AU - Liebow, Mark
AU - Maynadie, Marc
AU - McKay, James
AU - Melbye, Mads
AU - Miligi, Lucia
AU - Milne, Roger L.
AU - Molina, Thierry J.
AU - Morton, Lindsay M.
AU - North, Kari E.
AU - Offit, Kenneth
AU - Padoan, Marina
AU - Patel, Alpa V.
AU - Piro, Sara
AU - Ravichandran, Vignesh
AU - Riboli, Elio
AU - de Sanjose, Silvia
AU - Severson, Richard K.
AU - Southey, Melissa C.
AU - Staines, Anthony
AU - Stewart, Carolyn
AU - Travis, Ruth C.
AU - Weiderpass, Elisabete
AU - Weinstein, Stephanie
AU - Zheng, Tongzhang
AU - Chanock, Stephen J.
AU - Chatterjee, Nilanjan
AU - Rothman, Nathaniel
AU - Birmann, Brenda M.
AU - Cerhan, James R.
AU - Berndt, Sonja I.
N1 - Publisher Copyright:
© Copyright © 2020 Moore, Kane, Wang, Panagiotou, Teras, Monnereau, Wong Doo, Machiela, Skibola, Slager, Salles, Camp, Bracci, Nieters, Vermeulen, Vijai, Smedby, Zhang, Vajdic, Cozen, Spinelli, Hjalgrim, Giles, Link, Clavel, Arslan, Purdue, Tinker, Albanes, Ferri, Habermann, Adami, Becker, Benavente, Bisanzi, Boffetta, Brennan, Brooks-Wilson, Canzian, Conde, Cox, Curtin, Foretova, Gapstur, Ghesquières, Glenn, Glimelius, Jackson, Lan, Liebow, Maynadie, McKay, Melbye, Miligi, Milne, Molina, Morton, North, Offit, Padoan, Patel, Piro, Ravichandran, Riboli, de Sanjose, Severson, Southey, Staines, Stewart, Travis, Weiderpass, Weinstein, Zheng, Chanock, Chatterjee, Rothman, Birmann, Cerhan and Berndt.
PY - 2020/1/28
Y1 - 2020/1/28
N2 - Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
AB - Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
KW - chronic lymphocytic leukemia
KW - diffuse large B-cell lymphoma
KW - follicular lymphoma
KW - genetics
KW - height
KW - marginal zone lymphoma
KW - non-Hodgkin lymphoma
KW - polygenic risk score
UR - https://www.scopus.com/pages/publications/85079502127
U2 - 10.3389/fonc.2019.01539
DO - 10.3389/fonc.2019.01539
M3 - Article
AN - SCOPUS:85079502127
SN - 2234-943X
VL - 9
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 1539
ER -