Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Lucia Conde; Eran Halperin; Nicholas K. Akers; Kevin M. Brown; Karin E. Smedby; Nathaniel Rothman; Alexandra Nieters; Susan L. Slager; Angela Brooks-Wilson; Luz Agana; Jacques Riby; Jianjun Liu; Hans Olov Adami; Hatef Darabi; Henrik Hjalgrim; Hui Qi Low; Keith Humphreys; Mads Melbye; Ellen T. Chang; Bengt Glimelius; Wendy Cozen; Scott Davis; Patricia Hartge; Lindsay M. Morton; Maryjean Schenk; Sophia S. Wang; Bruce Armstrong; Anne Kricker; Sam Milliken; Mark P. Purdue; Claire M. Vajdic; Peter Boyle; Qing Lan; Shelia H. Zahm; Yawei Zhang; Tongzhang Zheng; Nikolaus Becker; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Katja Butterbach; Pierluigi Cocco; Lenka Foretova; Marc Maynadié; Silvia De Sanjosé; Anthony Staines; John J. Spinelli; Sara J. Achenbach; Timothy G. Call; Nicola J. Camp; Martha Glenn; Neil E. Caporaso; James R. Cerhan; Julie M. Cunningham; Lynn R. Goldin; Curtis A. Hanson; Neil E. Kay; Mark C. Lanasa; Jose F. Leis; Gerald E. Marti; Kari G. Rabe; Laura Z. Rassenti; Logan G. Spector; Sara S. Strom; Celine M. Vachon; J. Brice Weinberg; Elizabeth A. Holly; Stephen Chanock; Martyn T. Smith; Paige M. Bracci; Christine F. Skibola

doi:10.1038/ng.626

Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Lucia Conde
, Eran Halperin
, Nicholas K. Akers
, Kevin M. Brown
, Karin E. Smedby
, Nathaniel Rothman
, Alexandra Nieters
, Susan L. Slager
, Angela Brooks-Wilson
, Luz Agana
, Jacques Riby
, Jianjun Liu
, Hans Olov Adami
, Hatef Darabi
, Henrik Hjalgrim
, Hui Qi Low
, Keith Humphreys
, Mads Melbye
, Ellen T. Chang
, Bengt Glimelius

Wendy Cozen, Scott Davis, Patricia Hartge, Lindsay M. Morton, Maryjean Schenk, Sophia S. Wang, Bruce Armstrong, Anne Kricker, Sam Milliken, Mark P. Purdue, Claire M. Vajdic, Peter Boyle, Qing Lan, Shelia H. Zahm, Yawei Zhang, Tongzhang Zheng, Nikolaus Becker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Katja Butterbach, Pierluigi Cocco, Lenka Foretova, Marc Maynadié, Silvia De Sanjosé, Anthony Staines, John J. Spinelli, Sara J. Achenbach, Timothy G. Call, Nicola J. Camp, Martha Glenn, Neil E. Caporaso, James R. Cerhan, Julie M. Cunningham, Lynn R. Goldin, Curtis A. Hanson, Neil E. Kay, Mark C. Lanasa, Jose F. Leis, Gerald E. Marti, Kari G. Rabe, Laura Z. Rassenti, Logan G. Spector, Sara S. Strom, Celine M. Vachon, J. Brice Weinberg, Elizabeth A. Holly, Stephen Chanock, Martyn T. Smith, Paige M. Bracci, Christine F. Skibola

Family , Population and Preventative Medicine

University of California at Berkeley
Tel Aviv University
International Computer Science Institute
Translational Genomics Research Institute
Karolinska Institutet
National Institutes of Health
German Cancer Research Center
University of Freiburg
Mayo Clinic Rochester, MN
Provincial Health Services Authority
Simon Fraser University
Agency for Science, Technology and Research, Singapore
Harvard University
Statens Serum Institut
Northern California Cancer Center
Stanford University
Uppsala University
University of Southern California
Fred Hutchinson Cancer Research Center
Wayne State University
City of Hope National Med Center
The University of Sydney
St. Vincent's Hospital Sydney
University of New South Wales
University of Strathclyde
Yale University
Institute Catala Oncologia
International Agency for Research on Cancer
University of Cagliari
Masaryk Memorial Cancer Institute
Université de Bourgogne
University College Dublin
University of British Columbia
University of Utah
Duke University
University of California at San Diego
University of Minnesota Twin Cities
University of Texas MD Anderson Cancer Center
University of California at San Francisco

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10^-29 and rs7755224, combined P = 2.00 × 10-19; r² = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10^-9).

Original language	English
Pages (from-to)	661-664
Number of pages	4
Journal	Nature Genetics
Volume	42
Issue number	8
DOIs	https://doi.org/10.1038/ng.626
State	Published - Aug 2010

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Conde, L., Halperin, E., Akers, N. K., Brown, K. M., Smedby, K. E., Rothman, N., Nieters, A., Slager, S. L., Brooks-Wilson, A., Agana, L., Riby, J., Liu, J., Adami, H. O., Darabi, H., Hjalgrim, H., Low, H. Q., Humphreys, K., Melbye, M., Chang, E. T., ... Skibola, C. F. (2010). Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nature Genetics, 42(8), 661-664. https://doi.org/10.1038/ng.626

@article{d71b8e8942524dabaa779e8464d8b970,

title = "Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32",

abstract = "To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10-29 and rs7755224, combined P = 2.00 × 10-19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10-9).",

author = "Lucia Conde and Eran Halperin and Akers, \{Nicholas K.\} and Brown, \{Kevin M.\} and Smedby, \{Karin E.\} and Nathaniel Rothman and Alexandra Nieters and Slager, \{Susan L.\} and Angela Brooks-Wilson and Luz Agana and Jacques Riby and Jianjun Liu and Adami, \{Hans Olov\} and Hatef Darabi and Henrik Hjalgrim and Low, \{Hui Qi\} and Keith Humphreys and Mads Melbye and Chang, \{Ellen T.\} and Bengt Glimelius and Wendy Cozen and Scott Davis and Patricia Hartge and Morton, \{Lindsay M.\} and Maryjean Schenk and Wang, \{Sophia S.\} and Bruce Armstrong and Anne Kricker and Sam Milliken and Purdue, \{Mark P.\} and Vajdic, \{Claire M.\} and Peter Boyle and Qing Lan and Zahm, \{Shelia H.\} and Yawei Zhang and Tongzhang Zheng and Nikolaus Becker and Yolanda Benavente and Paolo Boffetta and Paul Brennan and Katja Butterbach and Pierluigi Cocco and Lenka Foretova and Marc Maynadi{\'e} and \{De Sanjos{\'e}\}, Silvia and Anthony Staines and Spinelli, \{John J.\} and Achenbach, \{Sara J.\} and Call, \{Timothy G.\} and Camp, \{Nicola J.\} and Martha Glenn and Caporaso, \{Neil E.\} and Cerhan, \{James R.\} and Cunningham, \{Julie M.\} and Goldin, \{Lynn R.\} and Hanson, \{Curtis A.\} and Kay, \{Neil E.\} and Lanasa, \{Mark C.\} and Leis, \{Jose F.\} and Marti, \{Gerald E.\} and Rabe, \{Kari G.\} and Rassenti, \{Laura Z.\} and Spector, \{Logan G.\} and Strom, \{Sara S.\} and Vachon, \{Celine M.\} and Weinberg, \{J. Brice\} and Holly, \{Elizabeth A.\} and Stephen Chanock and Smith, \{Martyn T.\} and Bracci, \{Paige M.\} and Skibola, \{Christine F.\}",

year = "2010",

month = aug,

doi = "10.1038/ng.626",

language = "English",

volume = "42",

pages = "661--664",

journal = "Nature Genetics",

issn = "1061-4036",

number = "8",

}

Conde, L, Halperin, E, Akers, NK, Brown, KM, Smedby, KE, Rothman, N, Nieters, A, Slager, SL, Brooks-Wilson, A, Agana, L, Riby, J, Liu, J, Adami, HO, Darabi, H, Hjalgrim, H, Low, HQ, Humphreys, K, Melbye, M, Chang, ET, Glimelius, B, Cozen, W, Davis, S, Hartge, P, Morton, LM, Schenk, M, Wang, SS, Armstrong, B, Kricker, A, Milliken, S, Purdue, MP, Vajdic, CM, Boyle, P, Lan, Q, Zahm, SH, Zhang, Y, Zheng, T, Becker, N, Benavente, Y, Boffetta, P, Brennan, P, Butterbach, K, Cocco, P, Foretova, L, Maynadié, M, De Sanjosé, S, Staines, A, Spinelli, JJ, Achenbach, SJ, Call, TG, Camp, NJ, Glenn, M, Caporaso, NE, Cerhan, JR, Cunningham, JM, Goldin, LR, Hanson, CA, Kay, NE, Lanasa, MC, Leis, JF, Marti, GE, Rabe, KG, Rassenti, LZ, Spector, LG, Strom, SS, Vachon, CM, Weinberg, JB, Holly, EA, Chanock, S, Smith, MT, Bracci, PM & Skibola, CF 2010, 'Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32', Nature Genetics, vol. 42, no. 8, pp. 661-664. https://doi.org/10.1038/ng.626

TY - JOUR

T1 - Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

AU - Conde, Lucia

AU - Halperin, Eran

AU - Akers, Nicholas K.

AU - Brown, Kevin M.

AU - Smedby, Karin E.

AU - Rothman, Nathaniel

AU - Nieters, Alexandra

AU - Slager, Susan L.

AU - Brooks-Wilson, Angela

AU - Agana, Luz

AU - Riby, Jacques

AU - Liu, Jianjun

AU - Adami, Hans Olov

AU - Darabi, Hatef

AU - Hjalgrim, Henrik

AU - Low, Hui Qi

AU - Humphreys, Keith

AU - Melbye, Mads

AU - Chang, Ellen T.

AU - Glimelius, Bengt

AU - Cozen, Wendy

AU - Davis, Scott

AU - Hartge, Patricia

AU - Morton, Lindsay M.

AU - Schenk, Maryjean

AU - Wang, Sophia S.

AU - Armstrong, Bruce

AU - Kricker, Anne

AU - Milliken, Sam

AU - Purdue, Mark P.

AU - Vajdic, Claire M.

AU - Boyle, Peter

AU - Lan, Qing

AU - Zahm, Shelia H.

AU - Zhang, Yawei

AU - Zheng, Tongzhang

AU - Becker, Nikolaus

AU - Benavente, Yolanda

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Butterbach, Katja

AU - Cocco, Pierluigi

AU - Foretova, Lenka

AU - Maynadié, Marc

AU - De Sanjosé, Silvia

AU - Staines, Anthony

AU - Spinelli, John J.

AU - Achenbach, Sara J.

AU - Call, Timothy G.

AU - Camp, Nicola J.

AU - Glenn, Martha

AU - Caporaso, Neil E.

AU - Cerhan, James R.

AU - Cunningham, Julie M.

AU - Goldin, Lynn R.

AU - Hanson, Curtis A.

AU - Kay, Neil E.

AU - Lanasa, Mark C.

AU - Leis, Jose F.

AU - Marti, Gerald E.

AU - Rabe, Kari G.

AU - Rassenti, Laura Z.

AU - Spector, Logan G.

AU - Strom, Sara S.

AU - Vachon, Celine M.

AU - Weinberg, J. Brice

AU - Holly, Elizabeth A.

AU - Chanock, Stephen

AU - Smith, Martyn T.

AU - Bracci, Paige M.

AU - Skibola, Christine F.

PY - 2010/8

Y1 - 2010/8

N2 - To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10-29 and rs7755224, combined P = 2.00 × 10-19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10-9).

AB - To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 × 10-29 and rs7755224, combined P = 2.00 × 10-19; r2 = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 × 10-9).

UR - https://www.scopus.com/pages/publications/77955091394

U2 - 10.1038/ng.626

DO - 10.1038/ng.626

M3 - Article

C2 - 20639881

AN - SCOPUS:77955091394

SN - 1061-4036

VL - 42

SP - 661

EP - 664

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

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