Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

David Mu; Liyun Chen; Xiping Zhang; Lei Hoon See; Christina M. Koch; Clifford Yen; James Jiayuan Tong; Lori Spiegel; Ken C.Q. Nguyen; Allyson Servoss; Yue Peng; Lin Pei; Jeffrey R. Marks; Scott Lowe; Timothy Hoey; Lily Yeh Jan; W. Richard McCombie; Michael H. Wigler; Scott Powers

doi:10.1016/S1535-6108(03)00054-0

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

David Mu
, Liyun Chen
, Xiping Zhang
, Lei Hoon See
, Christina M. Koch
, Clifford Yen
, James Jiayuan Tong
, Lori Spiegel
, Ken C.Q. Nguyen
, Allyson Servoss
, Yue Peng
, Lin Pei
, Jeffrey R. Marks
, Scott Lowe
, Timothy Hoey
, Lily Yeh Jan
, W. Richard McCombie
, Michael H. Wigler
, Scott Powers

Pathology

Tularik Inc.
Cold Spring Harbor Laboratory
Amgen Incorporated
Duke University
University of California at San Francisco

Research output: Contribution to journal › Article › peer-review

224 Scopus citations

Abstract

Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.

Original language	English
Pages (from-to)	297-302
Number of pages	6
Journal	Cancer Cell
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/S1535-6108(03)00054-0
State	Published - Mar 2003

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Mu, D., Chen, L., Zhang, X., See, L. H., Koch, C. M., Yen, C., Tong, J. J., Spiegel, L., Nguyen, K. C. Q., Servoss, A., Peng, Y., Pei, L., Marks, J. R., Lowe, S., Hoey, T., Jan, L. Y., McCombie, W. R., Wigler, M. H., & Powers, S. (2003). Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3(3), 297-302. https://doi.org/10.1016/S1535-6108(03)00054-0

@article{5e49c12402a3447a9fbf1a7bd8fcb990,

title = "Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene",

abstract = "Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10\% of breast tumors and overexpressed from 5-fold to over 100-fold in 44\% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.",

author = "David Mu and Liyun Chen and Xiping Zhang and See, \{Lei Hoon\} and Koch, \{Christina M.\} and Clifford Yen and Tong, \{James Jiayuan\} and Lori Spiegel and Nguyen, \{Ken C.Q.\} and Allyson Servoss and Yue Peng and Lin Pei and Marks, \{Jeffrey R.\} and Scott Lowe and Timothy Hoey and Jan, \{Lily Yeh\} and McCombie, \{W. Richard\} and Wigler, \{Michael H.\} and Scott Powers",

year = "2003",

month = mar,

doi = "10.1016/S1535-6108(03)00054-0",

language = "English",

volume = "3",

pages = "297--302",

journal = "Cancer Cell",

issn = "1535-6108",

number = "3",

}

Mu, D, Chen, L, Zhang, X, See, LH, Koch, CM, Yen, C, Tong, JJ, Spiegel, L, Nguyen, KCQ, Servoss, A, Peng, Y, Pei, L, Marks, JR, Lowe, S, Hoey, T, Jan, LY, McCombie, WR, Wigler, MH & Powers, S 2003, 'Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene', Cancer Cell, vol. 3, no. 3, pp. 297-302. https://doi.org/10.1016/S1535-6108(03)00054-0

TY - JOUR

T1 - Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

AU - Mu, David

AU - Chen, Liyun

AU - Zhang, Xiping

AU - See, Lei Hoon

AU - Koch, Christina M.

AU - Yen, Clifford

AU - Tong, James Jiayuan

AU - Spiegel, Lori

AU - Nguyen, Ken C.Q.

AU - Servoss, Allyson

AU - Peng, Yue

AU - Pei, Lin

AU - Marks, Jeffrey R.

AU - Lowe, Scott

AU - Hoey, Timothy

AU - Jan, Lily Yeh

AU - McCombie, W. Richard

AU - Wigler, Michael H.

AU - Powers, Scott

PY - 2003/3

Y1 - 2003/3

N2 - Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.

AB - Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.

UR - https://www.scopus.com/pages/publications/0038587789

U2 - 10.1016/S1535-6108(03)00054-0

DO - 10.1016/S1535-6108(03)00054-0

M3 - Article

C2 - 12676587

AN - SCOPUS:0038587789

SN - 1535-6108

VL - 3

SP - 297

EP - 302

JO - Cancer Cell

JF - Cancer Cell

IS - 3

ER -

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

Abstract

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