TY - GEN
T1 - Geometrical analysis of bursting pacemaker neurons generated by computational models
T2 - Comparison to in vitro pre-bötzinger complex bursting neurons
AU - Cordovez, Juan M.
AU - Wilson, Christopher G.
AU - Solomon, Irene C.
PY - 2010
Y1 - 2010
N2 - Despite an incredible amount of progress toward understanding respiratory rhythm generation through the use of reduced mathematical models, controversy exists concerning the role of various ionic conductances in generating bursting behavior. Moreover, the dynamical behavior of these model neurons has not been examined. Here, we have used two well described pre-Bötzinger complex (pre-BötC) pacemaker neuron models to investigate their dynamical features. Based on our observations, we identify one of the models to better represent the general characteristics of the bursting dynamics and propose additional modifications to better capture the dynamics of our own experimental recordings.
AB - Despite an incredible amount of progress toward understanding respiratory rhythm generation through the use of reduced mathematical models, controversy exists concerning the role of various ionic conductances in generating bursting behavior. Moreover, the dynamical behavior of these model neurons has not been examined. Here, we have used two well described pre-Bötzinger complex (pre-BötC) pacemaker neuron models to investigate their dynamical features. Based on our observations, we identify one of the models to better represent the general characteristics of the bursting dynamics and propose additional modifications to better capture the dynamics of our own experimental recordings.
UR - https://www.scopus.com/pages/publications/77952297667
U2 - 10.1007/978-1-4419-5692-7_9
DO - 10.1007/978-1-4419-5692-7_9
M3 - Conference contribution
C2 - 20217318
AN - SCOPUS:77952297667
SN - 9781441956910
T3 - Advances in Experimental Medicine and Biology
SP - 45
EP - 48
BT - New Frontiers in Respiratory Control
A2 - Homma, Ikuo
A2 - Onimaru, Hiroshi
A2 - Fukuchi, Yoshinosuke
ER -