HIGH INCIDENCE OF TUBERCULOSIS INFECTION IN HIV-EXPOSED CHILDREN EXITING AN ISONIAZID PREVENTIVE THERAPY TRIAL

IMPAACT P1041 Team

doi:10.1097/INF.0000000000001946

HIGH INCIDENCE OF TUBERCULOSIS INFECTION IN HIV-EXPOSED CHILDREN EXITING AN ISONIAZID PREVENTIVE THERAPY TRIAL

IMPAACT P1041 Team

Pediatrics

Emory University
Stellenbosch University
Texas Children's Hospital Houston
Harvard University
Pennsylvania State University
University of Miami

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.

Original language	English
Pages (from-to)	E254-E256
Journal	Pediatric Infectious Disease Journal
Volume	37
Issue number	10
DOIs	https://doi.org/10.1097/INF.0000000000001946
State	Published - Oct 1 2018

Keywords

Children
HIV
Tuberculin
Tuberculosis

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10.1097/INF.0000000000001946

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title = "HIGH INCIDENCE OF TUBERCULOSIS INFECTION IN HIV-EXPOSED CHILDREN EXITING AN ISONIAZID PREVENTIVE THERAPY TRIAL",

abstract = "Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.",

keywords = "Children, HIV, Tuberculin, Tuberculosis",

author = "\{IMPAACT P1041 Team\} and Cranmer, \{Lisa M.\} and Draper, \{Heather R.\} and Mandalakas, \{Anna M.\} and Soyeon Kim and George McSherry and Emma Krezinski and Joan Coetzee and Charles Mitchell and Sharon Nachman and \{van der Linde\}, Mercia and Cotton, \{Mark F.\} and Hesseling, \{Anneke C.\}",

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doi = "10.1097/INF.0000000000001946",

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journal = "Pediatric Infectious Disease Journal",

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AU - IMPAACT P1041 Team

AU - Cranmer, Lisa M.

AU - Draper, Heather R.

AU - Mandalakas, Anna M.

AU - Kim, Soyeon

AU - McSherry, George

AU - Krezinski, Emma

AU - Coetzee, Joan

AU - Mitchell, Charles

AU - Nachman, Sharon

AU - van der Linde, Mercia

AU - Cotton, Mark F.

AU - Hesseling, Anneke C.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.

AB - Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.

KW - Children

KW - HIV

KW - Tuberculin

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/85053316056

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DO - 10.1097/INF.0000000000001946

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AN - SCOPUS:85053316056

SN - 0891-3668

VL - 37

SP - E254-E256

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 10

ER -

HIGH INCIDENCE OF TUBERCULOSIS INFECTION IN HIV-EXPOSED CHILDREN EXITING AN ISONIAZID PREVENTIVE THERAPY TRIAL

Abstract

Keywords

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