TY - GEN
T1 - High resolution capacitance sensor array for real-time monitoring of cell viability
AU - Naviasky, Emily
AU - Datta-Chaudhuri, Timir
AU - Abshire, Pamela
PY - 2014
Y1 - 2014
N2 - Capacitance based cell sensing has shown promising results for monitoring cell viability. Studies have shown direct correlation between cell health and measured capacitance. Prior sensors have used charge based capacitance measurement, which has limitations in offset correction, range, and resolution. An alternative approach to monitoring small changes in electrode capacitance is to measure frequency change of a current controlled ring oscillator containing a sensing electrode that acts as a variable capacitor. This sensor design has no need for on-chip offset correction, because the range of the digital output of the chip depends on the counter size rather than input voltage. In addition, the resolution for this sensor is limited only by the amount of read time given to each pixel. For an oscillation frequency of 40 MHz the sensors are expected to achieve a resolution of 2.6 aF. The sensor has been incorporated into a 4×4 array prototype which will be packaged for operation in cell culture and used in viability studies of mammalian cells.
AB - Capacitance based cell sensing has shown promising results for monitoring cell viability. Studies have shown direct correlation between cell health and measured capacitance. Prior sensors have used charge based capacitance measurement, which has limitations in offset correction, range, and resolution. An alternative approach to monitoring small changes in electrode capacitance is to measure frequency change of a current controlled ring oscillator containing a sensing electrode that acts as a variable capacitor. This sensor design has no need for on-chip offset correction, because the range of the digital output of the chip depends on the counter size rather than input voltage. In addition, the resolution for this sensor is limited only by the amount of read time given to each pixel. For an oscillation frequency of 40 MHz the sensors are expected to achieve a resolution of 2.6 aF. The sensor has been incorporated into a 4×4 array prototype which will be packaged for operation in cell culture and used in viability studies of mammalian cells.
KW - capacitance measurement
KW - cell culture
KW - lab on chip
UR - https://www.scopus.com/pages/publications/84907415442
U2 - 10.1109/ISCAS.2014.6865215
DO - 10.1109/ISCAS.2014.6865215
M3 - Conference contribution
AN - SCOPUS:84907415442
SN - 9781479934324
T3 - Proceedings - IEEE International Symposium on Circuits and Systems
SP - 634
EP - 637
BT - 2014 IEEE International Symposium on Circuits and Systems, ISCAS 2014
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2014 IEEE International Symposium on Circuits and Systems, ISCAS 2014
Y2 - 1 June 2014 through 5 June 2014
ER -