TY - GEN
T1 - High-resolution imaging characterization of bladder muscle contractility
AU - Jain, A. V.
AU - Wang, Z. G.
AU - Pan, Y. T.
PY - 2007
Y1 - 2007
N2 - This study explores the use of high-speed optical coherence tomography (OCT) to characterize the dynamic morphophysiology of the bladder detrusor muscles, thus providing a tool to analyze detrusor functions and the mechanisms leading to geriatric incontinence. Ex vivo OCT imaging study was performed to analyze the temperature dependence of the spontaneous contractility of rabbit bladder. The time-lapsed OCT images were segmented and FFT was implemented to analyze the changes of the detrusor muscle contractility with temperature. The results show that the bladder contractility increases with temperature. The data suggest that, owing to the high temporal and high spatial resolutions, time-lapse OCT can provide a new platform to systemically study detrusor muscle dynamic morphophysiology and functions under varying conditions (e.g. field stimulation, pharmacological intervention etc.), critical to the diagnosis of detrusor dysfunction and the mechanisms leading to geriatric incontinence.
AB - This study explores the use of high-speed optical coherence tomography (OCT) to characterize the dynamic morphophysiology of the bladder detrusor muscles, thus providing a tool to analyze detrusor functions and the mechanisms leading to geriatric incontinence. Ex vivo OCT imaging study was performed to analyze the temperature dependence of the spontaneous contractility of rabbit bladder. The time-lapsed OCT images were segmented and FFT was implemented to analyze the changes of the detrusor muscle contractility with temperature. The results show that the bladder contractility increases with temperature. The data suggest that, owing to the high temporal and high spatial resolutions, time-lapse OCT can provide a new platform to systemically study detrusor muscle dynamic morphophysiology and functions under varying conditions (e.g. field stimulation, pharmacological intervention etc.), critical to the diagnosis of detrusor dysfunction and the mechanisms leading to geriatric incontinence.
UR - https://www.scopus.com/pages/publications/48749097635
U2 - 10.1109/NEBC.2007.4413288
DO - 10.1109/NEBC.2007.4413288
M3 - Conference contribution
AN - SCOPUS:48749097635
SN - 1424410339
SN - 9781424410330
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 79
EP - 80
BT - 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd Annual Northeast Bioengineering Conference, NEBC
Y2 - 10 March 2007 through 11 March 2007
ER -