Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva

B. Rigas; R. A. Lewis; K. Frank Ausien; E. J. Corey; L. Levine

doi:10.1016/0003-9969(83)90058-4

Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva

B. Rigas
, R. A. Lewis
, K. Frank Ausien
, E. J. Corey
, L. Levine

Family , Population and Preventative Medicine

Harvard University
Brandeis University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Arachidonic-acid metabolites were identified in salivary secretions of rabbits, rats and man and in homogenates of rabbit parotid and submandibular glands. The following levels were determined in mixed saliva of healthy volunteers: PGE₂, 0.65 ± 0.8 ng/ml; PGF_2α, 0.41 ± 0.06 ng/ml; serologically active hydroxyeicosatetraenoic acids (HETE) 319.6 ± 36.6 ng/ml; serologically active 6-sulphidopeptide-containing leukotrienes 1.72 ± 0.21 ng/ml (all values mean ± SEM). In all instances, HETE markedly predominated over all other arachidonic-acid metabolites.

Original language	English
Pages (from-to)	1031-1035
Number of pages	5
Journal	Archives of Oral Biology
Volume	28
Issue number	11
DOIs	https://doi.org/10.1016/0003-9969(83)90058-4
State	Published - 1983

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title = "Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva",

abstract = "Arachidonic-acid metabolites were identified in salivary secretions of rabbits, rats and man and in homogenates of rabbit parotid and submandibular glands. The following levels were determined in mixed saliva of healthy volunteers: PGE2, 0.65 ± 0.8 ng/ml; PGF2α, 0.41 ± 0.06 ng/ml; serologically active hydroxyeicosatetraenoic acids (HETE) 319.6 ± 36.6 ng/ml; serologically active 6-sulphidopeptide-containing leukotrienes 1.72 ± 0.21 ng/ml (all values mean ± SEM). In all instances, HETE markedly predominated over all other arachidonic-acid metabolites.",

author = "B. Rigas and Lewis, \{R. A.\} and Ausien, \{K. Frank\} and Corey, \{E. J.\} and L. Levine",

year = "1983",

doi = "10.1016/0003-9969(83)90058-4",

language = "English",

volume = "28",

pages = "1031--1035",

journal = "Archives of Oral Biology",

issn = "0003-9969",

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T1 - Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva

AU - Rigas, B.

AU - Lewis, R. A.

AU - Ausien, K. Frank

AU - Corey, E. J.

AU - Levine, L.

PY - 1983

Y1 - 1983

N2 - Arachidonic-acid metabolites were identified in salivary secretions of rabbits, rats and man and in homogenates of rabbit parotid and submandibular glands. The following levels were determined in mixed saliva of healthy volunteers: PGE2, 0.65 ± 0.8 ng/ml; PGF2α, 0.41 ± 0.06 ng/ml; serologically active hydroxyeicosatetraenoic acids (HETE) 319.6 ± 36.6 ng/ml; serologically active 6-sulphidopeptide-containing leukotrienes 1.72 ± 0.21 ng/ml (all values mean ± SEM). In all instances, HETE markedly predominated over all other arachidonic-acid metabolites.

AB - Arachidonic-acid metabolites were identified in salivary secretions of rabbits, rats and man and in homogenates of rabbit parotid and submandibular glands. The following levels were determined in mixed saliva of healthy volunteers: PGE2, 0.65 ± 0.8 ng/ml; PGF2α, 0.41 ± 0.06 ng/ml; serologically active hydroxyeicosatetraenoic acids (HETE) 319.6 ± 36.6 ng/ml; serologically active 6-sulphidopeptide-containing leukotrienes 1.72 ± 0.21 ng/ml (all values mean ± SEM). In all instances, HETE markedly predominated over all other arachidonic-acid metabolites.

UR - https://www.scopus.com/pages/publications/0021008535

U2 - 10.1016/0003-9969(83)90058-4

DO - 10.1016/0003-9969(83)90058-4

M3 - Article

C2 - 6318707

AN - SCOPUS:0021008535

SN - 0003-9969

VL - 28

SP - 1031

EP - 1035

JO - Archives of Oral Biology

JF - Archives of Oral Biology

IS - 11

ER -

Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva

Abstract

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