TY - GEN
T1 - Image guided 3D OCT for early diagnosis of carcinoma in situ of the bladder
AU - Ren, Hugang
AU - Park, Ki Cheon
AU - Pan, Rubin
AU - Shroyer, Kenneth
AU - Waltzer, Wayne
AU - Pan, Yingtian
PY - 2012
Y1 - 2012
N2 - Bladder carcinoma in situ (CIS) remains a clinical challenge. We compare the efficacies and potential limitations of surface imaging modalities, e.g., white light (WL), fluorescence (FC), blue-light imaging (BL) and 3D optical coherence tomography (3D OCT) for early diagnosis of bladder CIS. SV40T transgenic mice, which develop carcinoma in situ in about 8 to 20 weeks then high grade papillary tumor in the bladder, were employed as the rodent carcinogenesis model to closely mimic human bladder CIS. A total of 30 mice (i.e., SV40T mice blinded with its back strain Balb/c mice) were enrolled in the study, including 20 with CIS and 10 with normal or benign lesions of the bladder mucosa. Our results show that the low diagnostic sensitivities and specificities of WL, FC and BL for early CIS were significantly enhanced by quantitative 3D OCT to 95.0% and 90.0%, suggesting the value of image-guided 3D OCT for future clinical diagnosis of CIS in vivo.
AB - Bladder carcinoma in situ (CIS) remains a clinical challenge. We compare the efficacies and potential limitations of surface imaging modalities, e.g., white light (WL), fluorescence (FC), blue-light imaging (BL) and 3D optical coherence tomography (3D OCT) for early diagnosis of bladder CIS. SV40T transgenic mice, which develop carcinoma in situ in about 8 to 20 weeks then high grade papillary tumor in the bladder, were employed as the rodent carcinogenesis model to closely mimic human bladder CIS. A total of 30 mice (i.e., SV40T mice blinded with its back strain Balb/c mice) were enrolled in the study, including 20 with CIS and 10 with normal or benign lesions of the bladder mucosa. Our results show that the low diagnostic sensitivities and specificities of WL, FC and BL for early CIS were significantly enhanced by quantitative 3D OCT to 95.0% and 90.0%, suggesting the value of image-guided 3D OCT for future clinical diagnosis of CIS in vivo.
KW - 3D optical coherence tomography
KW - Bladder cancer
KW - Blue-light imaging (BL)
KW - Carcinoma in situ
KW - Fluorescence cystoscopy
KW - White light
UR - https://www.scopus.com/pages/publications/84899095371
U2 - 10.1117/12.909021
DO - 10.1117/12.909021
M3 - Conference contribution
AN - SCOPUS:84899095371
SN - 9780819488565
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
PB - SPIE
T2 - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Y2 - 23 January 2012 through 25 January 2012
ER -