TY - JOUR
T1 - Immunization and MS
T2 - A summary of published evidence and recommendations
AU - Rutschmann, Olivier T.
AU - McCrory, Douglas C.
AU - Matchar, David B.
AU - Bourdette, Dennis
AU - Copperman, Lois
AU - Coyle, Patricia
AU - DeStafano, Frank
AU - Marrie, Thomas
AU - Miller, Deborah
AU - Phair, Cindy
AU - Richert, John
AU - Goodin, Douglas S.
AU - Armon, Carmel
AU - Frohman, Elliot M.
AU - Goldman, Robert S.
AU - Hammond, David
AU - Hsu, Chung Y.
AU - Kanner, Andres M.
AU - Lefkowitz, David S.
AU - Silverman, Isaac E.
AU - Sloan, Michael A.
AU - So, Yuen T.
PY - 2002/12/24
Y1 - 2002/12/24
N2 - Objective: To review the risk of MS exacerbations after infectious episodes potentially preventable by vaccination, and the risks and benefits of immunizing patients with MS. Methods: The authors searched MEDLINE (1966 to January 2001; U.S. National Library of Medicine, Bethesda, MD), HealthSTAR, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) database (Cinahl Information Systems, Glendale, CA) for English-language articles. Each study was summarized and rated for quality of evidence. Then feasible data were pooled and analyzed in metaanalysis. Results: The risk of contracting common infectious diseases in patients with MS is not well established. There is strong evidence for an increased risk of MS exacerbations during weeks around an infectious episode. There is strong evidence against an increased risk of MS exacerbation after influenza immunization. There is no evidence that hepatitis B, varicella, tetanus, or Bacille Calmette-Guerin vaccines increase the risk of MS exacerbations. Insufficient evidence was found for other vaccines. Conclusions: Evidence supports 1) strategies to minimize the risk of acquiring infectious diseases that may trigger exacerbations of MS; and 2) the safety of using influenza, hepatitis B, varicella, tetanus, and Bacille Calmette-Guerin (BCG) vaccines in patients with MS.
AB - Objective: To review the risk of MS exacerbations after infectious episodes potentially preventable by vaccination, and the risks and benefits of immunizing patients with MS. Methods: The authors searched MEDLINE (1966 to January 2001; U.S. National Library of Medicine, Bethesda, MD), HealthSTAR, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) database (Cinahl Information Systems, Glendale, CA) for English-language articles. Each study was summarized and rated for quality of evidence. Then feasible data were pooled and analyzed in metaanalysis. Results: The risk of contracting common infectious diseases in patients with MS is not well established. There is strong evidence for an increased risk of MS exacerbations during weeks around an infectious episode. There is strong evidence against an increased risk of MS exacerbation after influenza immunization. There is no evidence that hepatitis B, varicella, tetanus, or Bacille Calmette-Guerin vaccines increase the risk of MS exacerbations. Insufficient evidence was found for other vaccines. Conclusions: Evidence supports 1) strategies to minimize the risk of acquiring infectious diseases that may trigger exacerbations of MS; and 2) the safety of using influenza, hepatitis B, varicella, tetanus, and Bacille Calmette-Guerin (BCG) vaccines in patients with MS.
UR - https://www.scopus.com/pages/publications/0037168795
U2 - 10.1212/WNL.59.12.1837
DO - 10.1212/WNL.59.12.1837
M3 - Article
C2 - 12499473
AN - SCOPUS:0037168795
SN - 0028-3878
VL - 59
SP - 1837
EP - 1843
JO - Neurology
JF - Neurology
IS - 12
ER -