Abstract
We study the problem of sorting integer sequences and permutations by length-weighted reversals. We consider a wide class of cost functions, namely f(l) = lα for all α ≥ 0, where l is the length of the reversed subsequence. We present tight or nearly tight upper and lower bounds on the worst-case cost of sorting by reversals. Then we develop algorithms to approximate the optimal cost to sort a given input. Furthermore, we give polynomial-time algorithms to determine the optimal reversal sequence for a restricted but interesting class of sequences and cost functions. Our results have direct application in computational biology to the field of comparative genomics.
| Original language | English |
|---|---|
| Pages | 912-921 |
| Number of pages | 10 |
| State | Published - 2004 |
| Event | Proceedings of the Fifteenth Annual ACM-SIAM Symposium on Discrete Algorithms - New Orleans, LA., United States Duration: Jan 11 2004 → Jan 13 2004 |
Conference
| Conference | Proceedings of the Fifteenth Annual ACM-SIAM Symposium on Discrete Algorithms |
|---|---|
| Country/Territory | United States |
| City | New Orleans, LA. |
| Period | 01/11/04 → 01/13/04 |
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