TY - JOUR
T1 - Incidence, risk and protective factors of symptoms after colonoscopy
AU - Collatuzzo, Giulia
AU - Boffetta, Paolo
AU - Radaelli, Franco
AU - Cadoni, Sergio
AU - Hassan, Cesare
AU - Frazzoni, Leonardo
AU - Anderloni, Andrea
AU - Laterza, Liboria
AU - La Marca, Marina
AU - Rogai, Francesca
AU - Binda, Cecilia
AU - Montale, Amedeo
AU - Soriani, Paola
AU - Fabbri, Carlo
AU - Sacco, Marco
AU - Gallittu, Paolo
AU - Mura, Donatella
AU - Trovato, Cristina
AU - Vitale, Giovanna
AU - Mussetto, Alessandro
AU - Musso, Alessandro
AU - Conti, Clara Benedetta
AU - Manno, Mauro
AU - Repici, Alessandro
AU - Zagari, Rocco Maurizio
AU - Farioli, Andrea
AU - Fuccio, Lorenzo
N1 - Publisher Copyright:
© 2022 Editrice Gastroenterologica Italiana S.r.l.
PY - 2022/12
Y1 - 2022/12
N2 - Background: Few studies focused on minor adverse events which may develop after colonoscopy. Aims: To investigate the incidence and factors associated to post-colonoscopy symptoms. Methods: This is a prospective study conducted in 10 Italian hospitals. The main outcome was a cumulative score combining 10 gastrointestinal (GI) symptoms occurring the week following colonoscopy. The analyses were conducted via multivariate logistic regression. Results: Of 793 subjects included in the analysis, 361 (45.5%) complained the new onset of at least one GI symptom after the exam; one symptom was reported by 202 (25.5%), two or more symptoms by 159 (20.1%). Newly developed symptoms more frequently reported were epigastric/abdominal bloating (32.2%), pain (17.3%), and dyspeptic symptoms (17.9%). Symptoms were associated with female sex (odds ratio [OR]=2.54), increasing number of symptoms developed during bowel preparation intake (OR=1.35) and somatic symptoms (OR=1.27). An inverse association was observed with better mood (OR=0.74). A high-risk profile was identified, represented by women with bad mood and somatic symptoms (OR=8.81). Conclusion: About half of the patients develop de novo GI symptoms following colonoscopy. Improving bowel preparation tolerability may reduce the incidence of post-colonoscopy symptoms, especially in more vulnerable patients.
AB - Background: Few studies focused on minor adverse events which may develop after colonoscopy. Aims: To investigate the incidence and factors associated to post-colonoscopy symptoms. Methods: This is a prospective study conducted in 10 Italian hospitals. The main outcome was a cumulative score combining 10 gastrointestinal (GI) symptoms occurring the week following colonoscopy. The analyses were conducted via multivariate logistic regression. Results: Of 793 subjects included in the analysis, 361 (45.5%) complained the new onset of at least one GI symptom after the exam; one symptom was reported by 202 (25.5%), two or more symptoms by 159 (20.1%). Newly developed symptoms more frequently reported were epigastric/abdominal bloating (32.2%), pain (17.3%), and dyspeptic symptoms (17.9%). Symptoms were associated with female sex (odds ratio [OR]=2.54), increasing number of symptoms developed during bowel preparation intake (OR=1.35) and somatic symptoms (OR=1.27). An inverse association was observed with better mood (OR=0.74). A high-risk profile was identified, represented by women with bad mood and somatic symptoms (OR=8.81). Conclusion: About half of the patients develop de novo GI symptoms following colonoscopy. Improving bowel preparation tolerability may reduce the incidence of post-colonoscopy symptoms, especially in more vulnerable patients.
KW - Bowel preparation
KW - Colonoscopy
KW - Colonoscopy experience
KW - Post-colonoscopy symptoms
UR - https://www.scopus.com/pages/publications/85138757236
U2 - 10.1016/j.dld.2022.08.025
DO - 10.1016/j.dld.2022.08.025
M3 - Article
C2 - 36154988
AN - SCOPUS:85138757236
SN - 1590-8658
VL - 54
SP - 1698
EP - 1705
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 12
ER -