Increased serum neopterin levels in adults with Down syndrome

Pankaj D. Mehta; Bruce A. Patrick; Arthur J. Dalton; Bindu Patel; Sangita P. Mehta; Tuula Pirttila; Patricia K. Coyle

doi:10.1016/j.jneuroim.2005.03.010

Increased serum neopterin levels in adults with Down syndrome

Pankaj D. Mehta
, Bruce A. Patrick
, Arthur J. Dalton
, Bindu Patel
, Sangita P. Mehta
, Tuula Pirttila
, Patricia K. Coyle

Neurology

New York State Office for People with Developmental Disabilities
University of Eastern Finland

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We quantitated serum neopterin levels in Down syndrome (DS), normal controls, Alzheimer's disease, multiple sclerosis and other neurological diseases. We then analyzed the relationships with age, sex, apolipoprotein E (Apo E) phenotype, and amyloid beta protein 1-40 (Aβ40) and 1-42 (Aβ42) levels. Neopterin levels were higher in DS than all other groups. Levels in young DS (<40 years of age) and old DS (>41 years) were similar. There was no significant correlation between neopterin levels and age, sex, Apo E phenotype, and Aβ40 or Aβ42 levels in DS. This lack of correlation between neopterin and Aβ levels suggests that the higher neopterin concentrations in DS group reflect inflammatory cell activation rather than AD neuropathology.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	164
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.03.010
State	Published - Jul 2005

Keywords

Alzheimer's disease
Amyloid β protein 1-40 and 1-42
Down syndrome
Enzyme-linked immunosorbent assay
Neopterin

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10.1016/j.jneuroim.2005.03.010

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title = "Increased serum neopterin levels in adults with Down syndrome",

abstract = "We quantitated serum neopterin levels in Down syndrome (DS), normal controls, Alzheimer's disease, multiple sclerosis and other neurological diseases. We then analyzed the relationships with age, sex, apolipoprotein E (Apo E) phenotype, and amyloid beta protein 1-40 (Aβ40) and 1-42 (Aβ42) levels. Neopterin levels were higher in DS than all other groups. Levels in young DS (<40 years of age) and old DS (>41 years) were similar. There was no significant correlation between neopterin levels and age, sex, Apo E phenotype, and Aβ40 or Aβ42 levels in DS. This lack of correlation between neopterin and Aβ levels suggests that the higher neopterin concentrations in DS group reflect inflammatory cell activation rather than AD neuropathology.",

keywords = "Alzheimer's disease, Amyloid β protein 1-40 and 1-42, Down syndrome, Enzyme-linked immunosorbent assay, Neopterin",

author = "Mehta, \{Pankaj D.\} and Patrick, \{Bruce A.\} and Dalton, \{Arthur J.\} and Bindu Patel and Mehta, \{Sangita P.\} and Tuula Pirttila and Coyle, \{Patricia K.\}",

year = "2005",

month = jul,

doi = "10.1016/j.jneuroim.2005.03.010",

language = "English",

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journal = "Journal of Neuroimmunology",

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AU - Mehta, Pankaj D.

AU - Patrick, Bruce A.

AU - Dalton, Arthur J.

AU - Patel, Bindu

AU - Mehta, Sangita P.

AU - Pirttila, Tuula

AU - Coyle, Patricia K.

PY - 2005/7

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AB - We quantitated serum neopterin levels in Down syndrome (DS), normal controls, Alzheimer's disease, multiple sclerosis and other neurological diseases. We then analyzed the relationships with age, sex, apolipoprotein E (Apo E) phenotype, and amyloid beta protein 1-40 (Aβ40) and 1-42 (Aβ42) levels. Neopterin levels were higher in DS than all other groups. Levels in young DS (<40 years of age) and old DS (>41 years) were similar. There was no significant correlation between neopterin levels and age, sex, Apo E phenotype, and Aβ40 or Aβ42 levels in DS. This lack of correlation between neopterin and Aβ levels suggests that the higher neopterin concentrations in DS group reflect inflammatory cell activation rather than AD neuropathology.

KW - Alzheimer's disease

KW - Amyloid β protein 1-40 and 1-42

KW - Down syndrome

KW - Enzyme-linked immunosorbent assay

KW - Neopterin

UR - https://www.scopus.com/pages/publications/20444439420

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AN - SCOPUS:20444439420

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SP - 129

EP - 133

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Increased serum neopterin levels in adults with Down syndrome

Abstract

Keywords

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