TY - GEN
T1 - Influence of extracellular [K+]o on inspiratory network complexity of phrenic and hypoglossal nerve discharge in arterially-perfused adult rat
AU - Shen, Tabitha Y.
AU - Ono, Kenichi
AU - Solomon, Irene C.
PY - 2010
Y1 - 2010
N2 - Many in vitro mammalian preparations are used to study multiple aspects of central respiratory control. In these preparations, recordings of respiratory-related outputs that range from individual and population neuronal activities to hypoglossal (XII) nerve output to phrenic (PHR) nerve discharge commonly are used. These reduced preparations typically are supplied with an artificial cerebral spinal fluid (aCSF) containing an extracellular potassium level ([K+]o ) elevated above physiological levels in order to increase excitability and maintain a stable respiratory output. To begin to investigate the effects of [K+]o on the relationship between PHR and XII phase components, as well as the complexity underlying their respiratoryrelated network components, we examined the effects of various [K+]o levels on simultaneously recorded PHR and XII nerve activities in an arterially-perfused adult rat preparation.
AB - Many in vitro mammalian preparations are used to study multiple aspects of central respiratory control. In these preparations, recordings of respiratory-related outputs that range from individual and population neuronal activities to hypoglossal (XII) nerve output to phrenic (PHR) nerve discharge commonly are used. These reduced preparations typically are supplied with an artificial cerebral spinal fluid (aCSF) containing an extracellular potassium level ([K+]o ) elevated above physiological levels in order to increase excitability and maintain a stable respiratory output. To begin to investigate the effects of [K+]o on the relationship between PHR and XII phase components, as well as the complexity underlying their respiratoryrelated network components, we examined the effects of various [K+]o levels on simultaneously recorded PHR and XII nerve activities in an arterially-perfused adult rat preparation.
UR - https://www.scopus.com/pages/publications/77952316616
U2 - 10.1007/978-1-4419-5692-7_36
DO - 10.1007/978-1-4419-5692-7_36
M3 - Conference contribution
C2 - 20217345
AN - SCOPUS:77952316616
SN - 9781441956910
T3 - Advances in Experimental Medicine and Biology
SP - 181
EP - 184
BT - New Frontiers in Respiratory Control
A2 - Homma, Ikuo
A2 - Onimaru, Hiroshi
A2 - Fukuchi, Yoshinosuke
ER -