@inproceedings{0d0e485dbe2d48aca1a3591ef5115813,
title = "Inhibiting staphylococcus aureus antibiotic resistance via photo-disassembly of membrane microdomains",
abstract = "The rapid evolution of antibiotic resistance increasingly challenges the successful treatment of S. aureus infections. Here, we present an unconventional treatment approach by disassembly its membrane microdomains via pulsed laser photolysis of staphyloxanthin. After staphyloxanthin photolysis, membrane permeabilization, fluidification, and membrane protein detachment, were found the underlying mechanisms to malfunction its defense to several major classes of conventional antibiotics. Through resistance selection study, we found pulsed laser treatment completely depleted staphyloxanthin virulence. More importantly, laser treatment further inhibited development of resistance for several major classes of conventional antibiotics including fluoroquinolones, tetracyclines, aminoglycosides, and oxazolidinones. Collectively, this work highlights a novel platform to revive conventional antibiotics to treat S. aureus infections.",
keywords = "Antibiotic resistance, Membrane microdomain, MRSA, Photolysis, Phototherapy, Pulsed laser, S. aureus, Staphyloxanthin",
author = "Jie Hui and Dong, \{Pu Ting\} and Lijia Liang and Taraknath Mandal and Junjie Li and Ulloa, \{Erlinda R.\} and Yuewei Zhan and Sebastian Jusuf and Cheng Zong and Seleem, \{Mohamed N.\} and Liu, \{George Y.\} and Qiang Cui and Cheng, \{Ji Xin\}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020 ; Conference date: 03-02-2020 Through 04-02-2020",
year = "2020",
doi = "10.1117/12.2543045",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Tianhong Dai and Jurgen Popp and Wu, \{Mei X.\}",
booktitle = "Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020",
}