International lung cancer consortium: Coordinated association study of 10 potential lung cancer susceptibility variants

Therese Truong; Wiebke Sauter; James D. McKay; H. Dean Hosgood; Carla Gallagher; Christopher I. Amos; Margaret Spitz; Joshua Muscat; Philip Lazarus; Thomas Illig; H. Erich Wichmann; Heike Bickeböller; Angela Risch; Hendrik Dienemann; Zuo Feng Zhang; Behnaz Pezeshki Naeim; Ping Yang; Shanbeh Zienolddiny; Aage Haugen; Loïc Le Marchand; Yun Chul Hong; Jin Hee Kim; Eric J. Duell; Angeline S. Andrew; Chikako Kiyohara; Hongbing Shen; Keitaro Matsuo; Takeshi Suzuki; Adeline Seow; Daniel P.K. Ng; Qing Lan; David Zaridze; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Vali Constantinescu; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Neil E. Caporaso; Demetrius Albanes; Michael Thun; Maria Teresa Landi; Joanna Trubicka; Marcin Lener; Jan Lubinski; Ying Wang; Amélie Chabrier; Paolo Boffetta; Paul Brennan; Rayjean J. Hung

doi:10.1093/carcin/bgq001

International lung cancer consortium: Coordinated association study of 10 potential lung cancer susceptibility variants

Therese Truong
, Wiebke Sauter
, James D. McKay
, H. Dean Hosgood
, Carla Gallagher
, Christopher I. Amos
, Margaret Spitz
, Joshua Muscat
, Philip Lazarus
, Thomas Illig
, H. Erich Wichmann
, Heike Bickeböller
, Angela Risch
, Hendrik Dienemann
, Zuo Feng Zhang
, Behnaz Pezeshki Naeim
, Ping Yang
, Shanbeh Zienolddiny
, Aage Haugen
, Loïc Le Marchand

Yun Chul Hong, Jin Hee Kim, Eric J. Duell, Angeline S. Andrew, Chikako Kiyohara, Hongbing Shen, Keitaro Matsuo, Takeshi Suzuki, Adeline Seow, Daniel P.K. Ng, Qing Lan, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Vali Constantinescu, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Neil E. Caporaso, Demetrius Albanes, Michael Thun, Maria Teresa Landi, Joanna Trubicka, Marcin Lener, Jan Lubinski, Ying Wang, Amélie Chabrier, Paolo Boffetta, Paul Brennan, Rayjean J. Hung

Family , Population and Preventative Medicine

International Agency for Research on Cancer
Université Paris-Saclay
Helmholtz Zentrum München - German Research Center for Environmental Health
Ludwig Maximilian University of Munich
National Institutes of Health
Pennsylvania State University
University of Texas MD Anderson Cancer Center
University of Göttingen
German Cancer Research Center
Heidelberg University
University of California at Los Angeles
Mayo Clinic Rochester, MN
National Institute of Occupational Health
University of Hawai'i at Mānoa
Seoul National University
Dartmouth College
Institute Catala Oncologia
Kyushu University
Nanjing Medical University
Aichi Cancer Center Hospital and Research Institute
National University of Singapore
Cancer Research Center
Institute of occupational medecine
Maria Sklodowska-Curie Institute of Oncology
Hungarian National Institute of Environmental Health
Specialized Institute of Hygiene and Epidemiology
Regional Authority of Public Health
National Institute of Public Health
Charles University
Masaryk Memorial Cancer Institute
Palacký University Olomouc
American Cancer Society
Pomeranian Medical University in Szczecin
Samuel Lununfeld Research Institute

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Background: Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancerrelated pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3). Methods: Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk. Results: Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 × 10^-4). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 × 10^-4]. Conclusion: This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.

Original language	English
Pages (from-to)	625-633
Number of pages	9
Journal	Carcinogenesis
Volume	31
Issue number	4
DOIs	https://doi.org/10.1093/carcin/bgq001
State	Published - Jan 27 2010

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Truong, T., Sauter, W., McKay, J. D., Hosgood, H. D., Gallagher, C., Amos, C. I., Spitz, M., Muscat, J., Lazarus, P., Illig, T., Wichmann, H. E., Bickeböller, H., Risch, A., Dienemann, H., Zhang, Z. F., Naeim, B. P., Yang, P., Zienolddiny, S., Haugen, A., ... Hung, R. J. (2010). International lung cancer consortium: Coordinated association study of 10 potential lung cancer susceptibility variants. Carcinogenesis, 31(4), 625-633. https://doi.org/10.1093/carcin/bgq001

@article{c3940b89e45441988bf38c9f19c16e29,

title = "International lung cancer consortium: Coordinated association study of 10 potential lung cancer susceptibility variants",

abstract = "Background: Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancerrelated pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3). Methods: Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk. Results: Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 × 10-4). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 × 10-4]. Conclusion: This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.",

author = "Therese Truong and Wiebke Sauter and McKay, \{James D.\} and Hosgood, \{H. Dean\} and Carla Gallagher and Amos, \{Christopher I.\} and Margaret Spitz and Joshua Muscat and Philip Lazarus and Thomas Illig and Wichmann, \{H. Erich\} and Heike Bickeb{\"o}ller and Angela Risch and Hendrik Dienemann and Zhang, \{Zuo Feng\} and Naeim, \{Behnaz Pezeshki\} and Ping Yang and Shanbeh Zienolddiny and Aage Haugen and Marchand, \{Lo{\"i}c Le\} and Hong, \{Yun Chul\} and Kim, \{Jin Hee\} and Duell, \{Eric J.\} and Andrew, \{Angeline S.\} and Chikako Kiyohara and Hongbing Shen and Keitaro Matsuo and Takeshi Suzuki and Adeline Seow and Ng, \{Daniel P.K.\} and Qing Lan and David Zaridze and Neonilia Szeszenia-Dabrowska and Jolanta Lissowska and Peter Rudnai and Eleonora Fabianova and Vali Constantinescu and Vladimir Bencko and Lenka Foretova and Vladimir Janout and Caporaso, \{Neil E.\} and Demetrius Albanes and Michael Thun and Landi, \{Maria Teresa\} and Joanna Trubicka and Marcin Lener and Jan Lubinski and Ying Wang and Am{\'e}lie Chabrier and Paolo Boffetta and Paul Brennan and Hung, \{Rayjean J.\}",

year = "2010",

month = jan,

day = "27",

doi = "10.1093/carcin/bgq001",

language = "English",

volume = "31",

pages = "625--633",

journal = "Carcinogenesis",

issn = "0143-3334",

number = "4",

}

Truong, T, Sauter, W, McKay, JD, Hosgood, HD, Gallagher, C, Amos, CI, Spitz, M, Muscat, J, Lazarus, P, Illig, T, Wichmann, HE, Bickeböller, H, Risch, A, Dienemann, H, Zhang, ZF, Naeim, BP, Yang, P, Zienolddiny, S, Haugen, A, Marchand, LL, Hong, YC, Kim, JH, Duell, EJ, Andrew, AS, Kiyohara, C, Shen, H, Matsuo, K, Suzuki, T, Seow, A, Ng, DPK, Lan, Q, Zaridze, D, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Constantinescu, V, Bencko, V, Foretova, L, Janout, V, Caporaso, NE, Albanes, D, Thun, M, Landi, MT, Trubicka, J, Lener, M, Lubinski, J, Wang, Y, Chabrier, A, Boffetta, P, Brennan, P & Hung, RJ 2010, 'International lung cancer consortium: Coordinated association study of 10 potential lung cancer susceptibility variants', Carcinogenesis, vol. 31, no. 4, pp. 625-633. https://doi.org/10.1093/carcin/bgq001

TY - JOUR

T1 - International lung cancer consortium

T2 - Coordinated association study of 10 potential lung cancer susceptibility variants

AU - Truong, Therese

AU - Sauter, Wiebke

AU - McKay, James D.

AU - Hosgood, H. Dean

AU - Gallagher, Carla

AU - Amos, Christopher I.

AU - Spitz, Margaret

AU - Muscat, Joshua

AU - Lazarus, Philip

AU - Illig, Thomas

AU - Wichmann, H. Erich

AU - Bickeböller, Heike

AU - Risch, Angela

AU - Dienemann, Hendrik

AU - Zhang, Zuo Feng

AU - Naeim, Behnaz Pezeshki

AU - Yang, Ping

AU - Zienolddiny, Shanbeh

AU - Haugen, Aage

AU - Marchand, Loïc Le

AU - Hong, Yun Chul

AU - Kim, Jin Hee

AU - Duell, Eric J.

AU - Andrew, Angeline S.

AU - Kiyohara, Chikako

AU - Shen, Hongbing

AU - Matsuo, Keitaro

AU - Suzuki, Takeshi

AU - Seow, Adeline

AU - Ng, Daniel P.K.

AU - Lan, Qing

AU - Zaridze, David

AU - Szeszenia-Dabrowska, Neonilia

AU - Lissowska, Jolanta

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Constantinescu, Vali

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Caporaso, Neil E.

AU - Albanes, Demetrius

AU - Thun, Michael

AU - Landi, Maria Teresa

AU - Trubicka, Joanna

AU - Lener, Marcin

AU - Lubinski, Jan

AU - Wang, Ying

AU - Chabrier, Amélie

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Hung, Rayjean J.

PY - 2010/1/27

Y1 - 2010/1/27

N2 - Background: Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancerrelated pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3). Methods: Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk. Results: Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 × 10-4). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 × 10-4]. Conclusion: This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.

AB - Background: Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancerrelated pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3). Methods: Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk. Results: Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 × 10-4). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 × 10-4]. Conclusion: This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.

UR - https://www.scopus.com/pages/publications/77950890482

U2 - 10.1093/carcin/bgq001

DO - 10.1093/carcin/bgq001

M3 - Article

C2 - 20106900

AN - SCOPUS:77950890482

SN - 0143-3334

VL - 31

SP - 625

EP - 633

JO - Carcinogenesis

JF - Carcinogenesis

IS - 4

ER -

International lung cancer consortium: Coordinated association study of 10 potential lung cancer susceptibility variants

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