Intrathecal production of measles-specific IgA in subacute sclerosing panencephalitis

A. Visudtibhan; P. D. Mehta; J. Kulczycki; P. K. Coyle; H. Thormar

doi:10.1111/j.1600-0404.1997.tb00247.x

Intrathecal production of measles-specific IgA in subacute sclerosing panencephalitis

A. Visudtibhan
, P. D. Mehta
, J. Kulczycki
, P. K. Coyle
, H. Thormar

Neurology

New York State Office for People with Developmental Disabilities
SUNY Downstate Health Sciences University
Institute of Psychiatry and Neurology, Warszawa
University of Iceland

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective - We measured measles-specific IgA in matched pairs of cerebrospinal fluid (CSF) and sera of patients with subacute sclerosing panencephalitis (SSPE), multiple sclerosis (MS), other central nervous system (CNS) infectious diseases (INF) and other neurological diseases (OND) by using enzyme linked immunosorbent assay. Materials and methods - CSF and sera from 23 patients with SSPE, 15 with MS, 14 with INF, and 15 with OND were included in the study. Results - The ratios of measles-specific IgA in CSF to serum were increased in SSPE patients compared to patients with MS, INF or OND. Conclusion - The data indicate a local production of measles-specific IgA in the CNS of SSPE patients.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Acta Neurologica Scandinavica
Volume	96
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0404.1997.tb00247.x
State	Published - 1997

Keywords

Enzyme linked immunosorbent assay
Immunoglobulin A
Measles virus
Subacute sclerosing panencephalitis

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10.1111/j.1600-0404.1997.tb00247.x

Cite this

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title = "Intrathecal production of measles-specific IgA in subacute sclerosing panencephalitis",

abstract = "Objective - We measured measles-specific IgA in matched pairs of cerebrospinal fluid (CSF) and sera of patients with subacute sclerosing panencephalitis (SSPE), multiple sclerosis (MS), other central nervous system (CNS) infectious diseases (INF) and other neurological diseases (OND) by using enzyme linked immunosorbent assay. Materials and methods - CSF and sera from 23 patients with SSPE, 15 with MS, 14 with INF, and 15 with OND were included in the study. Results - The ratios of measles-specific IgA in CSF to serum were increased in SSPE patients compared to patients with MS, INF or OND. Conclusion - The data indicate a local production of measles-specific IgA in the CNS of SSPE patients.",

keywords = "Enzyme linked immunosorbent assay, Immunoglobulin A, Measles virus, Subacute sclerosing panencephalitis",

author = "A. Visudtibhan and Mehta, \{P. D.\} and J. Kulczycki and Coyle, \{P. K.\} and H. Thormar",

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doi = "10.1111/j.1600-0404.1997.tb00247.x",

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T1 - Intrathecal production of measles-specific IgA in subacute sclerosing panencephalitis

AU - Visudtibhan, A.

AU - Mehta, P. D.

AU - Kulczycki, J.

AU - Coyle, P. K.

AU - Thormar, H.

PY - 1997

Y1 - 1997

N2 - Objective - We measured measles-specific IgA in matched pairs of cerebrospinal fluid (CSF) and sera of patients with subacute sclerosing panencephalitis (SSPE), multiple sclerosis (MS), other central nervous system (CNS) infectious diseases (INF) and other neurological diseases (OND) by using enzyme linked immunosorbent assay. Materials and methods - CSF and sera from 23 patients with SSPE, 15 with MS, 14 with INF, and 15 with OND were included in the study. Results - The ratios of measles-specific IgA in CSF to serum were increased in SSPE patients compared to patients with MS, INF or OND. Conclusion - The data indicate a local production of measles-specific IgA in the CNS of SSPE patients.

AB - Objective - We measured measles-specific IgA in matched pairs of cerebrospinal fluid (CSF) and sera of patients with subacute sclerosing panencephalitis (SSPE), multiple sclerosis (MS), other central nervous system (CNS) infectious diseases (INF) and other neurological diseases (OND) by using enzyme linked immunosorbent assay. Materials and methods - CSF and sera from 23 patients with SSPE, 15 with MS, 14 with INF, and 15 with OND were included in the study. Results - The ratios of measles-specific IgA in CSF to serum were increased in SSPE patients compared to patients with MS, INF or OND. Conclusion - The data indicate a local production of measles-specific IgA in the CNS of SSPE patients.

KW - Enzyme linked immunosorbent assay

KW - Immunoglobulin A

KW - Measles virus

KW - Subacute sclerosing panencephalitis

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JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

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Intrathecal production of measles-specific IgA in subacute sclerosing panencephalitis

Abstract

Keywords

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