Is NF-κB a culprit in type 2 diabetes?

Fei Chen

doi:10.1016/j.bbrc.2005.03.075

Is NF-κB a culprit in type 2 diabetes?

Fei Chen

Pathology

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-κB signaling. Earlier studies indicated that IKKβ was the key for the development of insulin resistance. However, it was unknown whether IKKβ itself, or its downstream target, NF-κB, plays major roles in insulin resistance. New data suggest that NF-κB and NF-κB-regulated cytokines are crucial for the diabetogenesis.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Biochemical and Biophysical Research Communications
Volume	332
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2005.03.075
State	Published - Jun 24 2005

Keywords

Diabetes
IKKβ
Insulin resistance
NF-κB

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10.1016/j.bbrc.2005.03.075

Cite this

@article{511c560132254e8bba5eeb7f2337ef03,

title = "Is NF-κB a culprit in type 2 diabetes?",

abstract = "It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-κB signaling. Earlier studies indicated that IKKβ was the key for the development of insulin resistance. However, it was unknown whether IKKβ itself, or its downstream target, NF-κB, plays major roles in insulin resistance. New data suggest that NF-κB and NF-κB-regulated cytokines are crucial for the diabetogenesis.",

keywords = "Diabetes, IKKβ, Insulin resistance, NF-κB",

author = "Fei Chen",

year = "2005",

month = jun,

day = "24",

doi = "10.1016/j.bbrc.2005.03.075",

language = "English",

volume = "332",

pages = "1--3",

journal = "Biochemical and Biophysical Research Communications",