Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia

Aurelia M. Meloni-Ehrig; Carlos A. Tirado; Kuoping Chen; Jennifer Jahn; Stephany Suchan; Jay Scheerle; Maria Gabriela Crosby; Holly Meany; Nita Seibel; David Leitenberg; Deborah W. Heritage; Philip N. Mowrey

doi:10.1016/j.cancergencyto.2004.12.022

Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia

Aurelia M. Meloni-Ehrig
, Carlos A. Tirado
, Kuoping Chen
, Jennifer Jahn
, Stephany Suchan
, Jay Scheerle
, Maria Gabriela Crosby
, Holly Meany
, Nita Seibel
, David Leitenberg
, Deborah W. Heritage
, Philip N. Mowrey

Pathology

Quest Diagnostics Incorporated
Children's National Medical Center

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We present a case of del(14)(q21) as a sole abnormality in a 4-year-old boy diagnosed with precursor B-cell acute lymphoblastic leukemia (pre-B ALL). To our knowledge, this is the first case of isolated del(14)(q21) in pre-B ALL. Two pretreatment bone marrow samples obtained 5 days apart were analyzed by cytogenetics. The G-banded karyotypes of the two samples were similar, differing only in the ratio of normal/abnormal metaphases detected. Both samples showed a del(14)(q21) as the only abnormality. Fluorescence in situ hybridization performed using the probes TEL/AML1 and immunoglobulin heavy chain (IGH) showed no fusion involving the TEL and AML1 genes and only a single IGH signal in 20% of the interphase cells analyzed.

Original language	English
Pages (from-to)	82-85
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	161
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2004.12.022
State	Published - Aug 2005

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10.1016/j.cancergencyto.2004.12.022

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title = "Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia",

abstract = "We present a case of del(14)(q21) as a sole abnormality in a 4-year-old boy diagnosed with precursor B-cell acute lymphoblastic leukemia (pre-B ALL). To our knowledge, this is the first case of isolated del(14)(q21) in pre-B ALL. Two pretreatment bone marrow samples obtained 5 days apart were analyzed by cytogenetics. The G-banded karyotypes of the two samples were similar, differing only in the ratio of normal/abnormal metaphases detected. Both samples showed a del(14)(q21) as the only abnormality. Fluorescence in situ hybridization performed using the probes TEL/AML1 and immunoglobulin heavy chain (IGH) showed no fusion involving the TEL and AML1 genes and only a single IGH signal in 20\% of the interphase cells analyzed.",

author = "Meloni-Ehrig, \{Aurelia M.\} and Tirado, \{Carlos A.\} and Kuoping Chen and Jennifer Jahn and Stephany Suchan and Jay Scheerle and Crosby, \{Maria Gabriela\} and Holly Meany and Nita Seibel and David Leitenberg and Heritage, \{Deborah W.\} and Mowrey, \{Philip N.\}",

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doi = "10.1016/j.cancergencyto.2004.12.022",

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T1 - Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia

AU - Meloni-Ehrig, Aurelia M.

AU - Tirado, Carlos A.

AU - Chen, Kuoping

AU - Jahn, Jennifer

AU - Suchan, Stephany

AU - Scheerle, Jay

AU - Crosby, Maria Gabriela

AU - Meany, Holly

AU - Seibel, Nita

AU - Leitenberg, David

AU - Heritage, Deborah W.

AU - Mowrey, Philip N.

PY - 2005/8

Y1 - 2005/8

N2 - We present a case of del(14)(q21) as a sole abnormality in a 4-year-old boy diagnosed with precursor B-cell acute lymphoblastic leukemia (pre-B ALL). To our knowledge, this is the first case of isolated del(14)(q21) in pre-B ALL. Two pretreatment bone marrow samples obtained 5 days apart were analyzed by cytogenetics. The G-banded karyotypes of the two samples were similar, differing only in the ratio of normal/abnormal metaphases detected. Both samples showed a del(14)(q21) as the only abnormality. Fluorescence in situ hybridization performed using the probes TEL/AML1 and immunoglobulin heavy chain (IGH) showed no fusion involving the TEL and AML1 genes and only a single IGH signal in 20% of the interphase cells analyzed.

AB - We present a case of del(14)(q21) as a sole abnormality in a 4-year-old boy diagnosed with precursor B-cell acute lymphoblastic leukemia (pre-B ALL). To our knowledge, this is the first case of isolated del(14)(q21) in pre-B ALL. Two pretreatment bone marrow samples obtained 5 days apart were analyzed by cytogenetics. The G-banded karyotypes of the two samples were similar, differing only in the ratio of normal/abnormal metaphases detected. Both samples showed a del(14)(q21) as the only abnormality. Fluorescence in situ hybridization performed using the probes TEL/AML1 and immunoglobulin heavy chain (IGH) showed no fusion involving the TEL and AML1 genes and only a single IGH signal in 20% of the interphase cells analyzed.

UR - https://www.scopus.com/pages/publications/23244432817

U2 - 10.1016/j.cancergencyto.2004.12.022

DO - 10.1016/j.cancergencyto.2004.12.022

M3 - Article

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AN - SCOPUS:23244432817

SN - 0165-4608

VL - 161

SP - 82

EP - 85

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Isolated del(14)(q21) in a case of precursor B-cell acute lymphoblastic leukemia

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