JNK-induced apoptosis, compensatory growth, and cancer stem cells

Fei Chen

doi:10.1158/0008-5472.CAN-11-1982

JNK-induced apoptosis, compensatory growth, and cancer stem cells

Fei Chen

Pathology

Research output: Contribution to journal › Review article › peer-review

179 Scopus citations

Abstract

Overwhelming evidence suggests that c-jun-NH₂-kinases (JNK) are a set of key stress-responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, JNKs have also been implicated in the malignant transformation and tumorigenesis of cells. This review attempts to reconcile these 2 contradictory functions of JNKs with recent discoveries on the role of JNKs in compensatory growth of neighboring cells and stem cells, which may provide new mechanistic understanding about the role of JNKs in the regulation of cancer stem cells and the pathogenesis of cancers.

Original language	English
Pages (from-to)	379-386
Number of pages	8
Journal	Cancer Research
Volume	72
Issue number	2
DOIs	https://doi.org/10.1158/0008-5472.CAN-11-1982
State	Published - Jan 15 2012

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abstract = "Overwhelming evidence suggests that c-jun-NH2-kinases (JNK) are a set of key stress-responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, JNKs have also been implicated in the malignant transformation and tumorigenesis of cells. This review attempts to reconcile these 2 contradictory functions of JNKs with recent discoveries on the role of JNKs in compensatory growth of neighboring cells and stem cells, which may provide new mechanistic understanding about the role of JNKs in the regulation of cancer stem cells and the pathogenesis of cancers.",

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AB - Overwhelming evidence suggests that c-jun-NH2-kinases (JNK) are a set of key stress-responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, JNKs have also been implicated in the malignant transformation and tumorigenesis of cells. This review attempts to reconcile these 2 contradictory functions of JNKs with recent discoveries on the role of JNKs in compensatory growth of neighboring cells and stem cells, which may provide new mechanistic understanding about the role of JNKs in the regulation of cancer stem cells and the pathogenesis of cancers.

UR - https://www.scopus.com/pages/publications/84855896864

U2 - 10.1158/0008-5472.CAN-11-1982

DO - 10.1158/0008-5472.CAN-11-1982

M3 - Review article

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JNK-induced apoptosis, compensatory growth, and cancer stem cells

Abstract

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