Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Gioia Di Credico; Valeria Edefonti; Jerry Polesel; Francesco Pauli; Nicola Torelli; Diego Serraino; Eva Negri; Daniele Luce; Isabelle Stucker; Keitaro Matsuo; Paul Brennan; Marta Vilensky; Leticia Fernandez; Maria Paula Curado; Ana Menezes; Alexander W. Daudt; Rosalina Koifman; Victor Wunsch-Filho; Ivana Holcatova; Wolfgang Ahrens; Pagona Lagiou; Lorenzo Simonato; Lorenzo Richiardi; Claire Healy; Kristina Kjaerheim; David I. Conway; Tatiana V. Macfarlane; Peter Thomson; Antonio Agudo; Ariana Znaor; Leonardo F. Boaventura Rios; Tatiana N. Toporcov; Silvia Franceschi; Rolando Herrero; Joshua Muscat; Andrew F. Olshan; Jose P. Zevallos; Carlo La Vecchia; Deborah M. Winn; Erich M. Sturgis; Guojun Li; Eleonora Fabianova; Jolanda Lissowska; Dana Mates; Peter Rudnai; Oxana Shangina; Beata Swiatkowska; Kirsten Moysich; Zuo Feng Zhang; Hal Morgenstern; Fabio Levi; Elaine Smith; Philip Lazarus; Cristina Bosetti; Werner Garavello; Karl Kelsey; Michael McClean; Heribert Ramroth; Chu Chen; Stephen M. Schwartz; Thomas L. Vaughan; Tongzhang Zheng; Gwenn Menvielle; Stefania Boccia; Gabriella Cadoni; Richard B. Hayes; Mark Purdue; Maura Gillison; Stimson Schantz; Guo Pei Yu; Hermann Brenner; Gypsyamber D'Souza; Neil D. Gross; Shu Chun Chuang; Paolo Boffetta; Mia Hashibe; Yuan Chin Amy Lee; Luigino Dal Maso

doi:10.1016/j.oraloncology.2019.05.006

Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Gioia Di Credico
, Valeria Edefonti
, Jerry Polesel
, Francesco Pauli
, Nicola Torelli
, Diego Serraino
, Eva Negri
, Daniele Luce
, Isabelle Stucker
, Keitaro Matsuo
, Paul Brennan
, Marta Vilensky
, Leticia Fernandez
, Maria Paula Curado
, Ana Menezes
, Alexander W. Daudt
, Rosalina Koifman
, Victor Wunsch-Filho
, Ivana Holcatova
, Wolfgang Ahrens

Pagona Lagiou, Lorenzo Simonato, Lorenzo Richiardi, Claire Healy, Kristina Kjaerheim, David I. Conway, Tatiana V. Macfarlane, Peter Thomson, Antonio Agudo, Ariana Znaor, Leonardo F. Boaventura Rios, Tatiana N. Toporcov, Silvia Franceschi, Rolando Herrero, Joshua Muscat, Andrew F. Olshan, Jose P. Zevallos, Carlo La Vecchia, Deborah M. Winn, Erich M. Sturgis, Guojun Li, Eleonora Fabianova, Jolanda Lissowska, Dana Mates, Peter Rudnai, Oxana Shangina, Beata Swiatkowska, Kirsten Moysich, Zuo Feng Zhang, Hal Morgenstern, Fabio Levi, Elaine Smith, Philip Lazarus, Cristina Bosetti, Werner Garavello, Karl Kelsey, Michael McClean, Heribert Ramroth, Chu Chen, Stephen M. Schwartz, Thomas L. Vaughan, Tongzhang Zheng, Gwenn Menvielle, Stefania Boccia, Gabriella Cadoni, Richard B. Hayes, Mark Purdue, Maura Gillison, Stimson Schantz, Guo Pei Yu, Hermann Brenner, Gypsyamber D'Souza, Neil D. Gross, Shu Chun Chuang, Paolo Boffetta, Mia Hashibe, Yuan Chin Amy Lee, Luigino Dal Maso

Family , Population and Preventative Medicine

University of Padua
University of Trieste
University of Milan
IRCCS Centro di Riferimento Oncologico - Aviano PN
Inserm U1085—IRSET
Institut national de la santé et de la recherche médicale
Aichi Cancer Center Hospital and Research Institute
International Agency for Research on Cancer
Universidad de Buenos Aires
National School of Public Health
Epidemiology - CIPE/ACCAMARGO
Universidade Federal de Pelotas
Hospital Moinhos de Vento
Fundação Oswaldo Cruz
Universidade de São Paulo
Charles University
Leibniz Institute for Prevention Research and Epidemiology
University of Bremen
National and Kapodistrian University of Athens
University of Turin
Trinity College Dublin
Cancer Registry of Norway Institute of Population-Based Cancer Research
University of Glasgow
University of Aberdeen
The University of Hong Kong
Institute Catala Oncologia
Pennsylvania State University
University of North Carolina at Chapel Hill
Washington University St. Louis
National Institutes of Health
University of Texas MD Anderson Cancer Center
Regional Authority of Public Health in BanskaBystrica
Maria Sklodowska-Curie Institute of Oncology
National Institute of Public Health
Hungarian National Institute of Environmental Health
Blokhin Cancer Research Center
Nofer Institute of Occupational Medicine
Roswell Park Cancer Institute
University of California at Los Angeles
University of Michigan, Ann Arbor
University of Lausanne
University of Iowa
Washington State University Spokane
IRCCS Istituto di ricerche farmacologiche Mario Negri - Milano, Bergamo, Ranica
University of Milan - Bicocca
Brown University
Boston University
Heidelberg University
Fred Hutchinson Cancer Research Center
Sorbonne Université
Fondazione Policlinico Universitario A.Gemelli IRCS
Catholic University of the Sacred Heart
New York University
Continuum Health Partners, Inc.
Peking University
German Cancer Research Center
Johns Hopkins University
National Health Research Institutes Taiwan
University of Utah

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Original language	English
Pages (from-to)	47-57
Number of pages	11
Journal	Oral Oncology
Volume	94
DOIs	https://doi.org/10.1016/j.oraloncology.2019.05.006
State	Published - Jul 2019

Keywords

Bivariate spline models
Cigarette smoking duration
Cigarette smoking intensity
Head and neck cancer
INHANCE
Laryngeal cancer
Oral cavity and pharyngeal cancers

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10.1016/j.oraloncology.2019.05.006

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Di Credico, G., Edefonti, V., Polesel, J., Pauli, F., Torelli, N., Serraino, D., Negri, E., Luce, D., Stucker, I., Matsuo, K., Brennan, P., Vilensky, M., Fernandez, L., Curado, M. P., Menezes, A., Daudt, A. W., Koifman, R., Wunsch-Filho, V., Holcatova, I., ... Dal Maso, L. (2019). Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach. Oral Oncology, 94, 47-57. https://doi.org/10.1016/j.oraloncology.2019.05.006

@article{b0420d144a834f68aa546b910a9965fc,

title = "Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach",

abstract = "Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.",

keywords = "Bivariate spline models, Cigarette smoking duration, Cigarette smoking intensity, Head and neck cancer, INHANCE, Laryngeal cancer, Oral cavity and pharyngeal cancers",

author = "\{Di Credico\}, Gioia and Valeria Edefonti and Jerry Polesel and Francesco Pauli and Nicola Torelli and Diego Serraino and Eva Negri and Daniele Luce and Isabelle Stucker and Keitaro Matsuo and Paul Brennan and Marta Vilensky and Leticia Fernandez and Curado, \{Maria Paula\} and Ana Menezes and Daudt, \{Alexander W.\} and Rosalina Koifman and Victor Wunsch-Filho and Ivana Holcatova and Wolfgang Ahrens and Pagona Lagiou and Lorenzo Simonato and Lorenzo Richiardi and Claire Healy and Kristina Kjaerheim and Conway, \{David I.\} and Macfarlane, \{Tatiana V.\} and Peter Thomson and Antonio Agudo and Ariana Znaor and \{Boaventura Rios\}, \{Leonardo F.\} and Toporcov, \{Tatiana N.\} and Silvia Franceschi and Rolando Herrero and Joshua Muscat and Olshan, \{Andrew F.\} and Zevallos, \{Jose P.\} and \{La Vecchia\}, Carlo and Winn, \{Deborah M.\} and Sturgis, \{Erich M.\} and Guojun Li and Eleonora Fabianova and Jolanda Lissowska and Dana Mates and Peter Rudnai and Oxana Shangina and Beata Swiatkowska and Kirsten Moysich and Zhang, \{Zuo Feng\} and Hal Morgenstern and Fabio Levi and Elaine Smith and Philip Lazarus and Cristina Bosetti and Werner Garavello and Karl Kelsey and Michael McClean and Heribert Ramroth and Chu Chen and Schwartz, \{Stephen M.\} and Vaughan, \{Thomas L.\} and Tongzhang Zheng and Gwenn Menvielle and Stefania Boccia and Gabriella Cadoni and Hayes, \{Richard B.\} and Mark Purdue and Maura Gillison and Stimson Schantz and Yu, \{Guo Pei\} and Hermann Brenner and Gypsyamber D'Souza and Gross, \{Neil D.\} and Chuang, \{Shu Chun\} and Paolo Boffetta and Mia Hashibe and Lee, \{Yuan Chin Amy\} and \{Dal Maso\}, Luigino",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = jul,

doi = "10.1016/j.oraloncology.2019.05.006",

language = "English",

volume = "94",

pages = "47--57",

journal = "Oral Oncology",

issn = "1368-8375",

}

Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, MP, Menezes, A, Daudt, AW, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, DI, Macfarlane, TV, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, LF, Toporcov, TN, Franceschi, S, Herrero, R, Muscat, J, Olshan, AF, Zevallos, JP, La Vecchia, C, Winn, DM, Sturgis, EM, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, ZF, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, McClean, M, Ramroth, H, Chen, C, Schwartz, SM, Vaughan, TL, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, RB, Purdue, M, Gillison, M, Schantz, S, Yu, GP, Brenner, H, D'Souza, G, Gross, ND, Chuang, SC, Boffetta, P, Hashibe, M, Lee, YCA & Dal Maso, L 2019, 'Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach', Oral Oncology, vol. 94, pp. 47-57. https://doi.org/10.1016/j.oraloncology.2019.05.006

TY - JOUR

T1 - Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer

T2 - A bivariate spline model approach

AU - Di Credico, Gioia

AU - Edefonti, Valeria

AU - Polesel, Jerry

AU - Pauli, Francesco

AU - Torelli, Nicola

AU - Serraino, Diego

AU - Negri, Eva

AU - Luce, Daniele

AU - Stucker, Isabelle

AU - Matsuo, Keitaro

AU - Brennan, Paul

AU - Vilensky, Marta

AU - Fernandez, Leticia

AU - Curado, Maria Paula

AU - Menezes, Ana

AU - Daudt, Alexander W.

AU - Koifman, Rosalina

AU - Wunsch-Filho, Victor

AU - Holcatova, Ivana

AU - Ahrens, Wolfgang

AU - Lagiou, Pagona

AU - Simonato, Lorenzo

AU - Richiardi, Lorenzo

AU - Healy, Claire

AU - Kjaerheim, Kristina

AU - Conway, David I.

AU - Macfarlane, Tatiana V.

AU - Thomson, Peter

AU - Agudo, Antonio

AU - Znaor, Ariana

AU - Boaventura Rios, Leonardo F.

AU - Toporcov, Tatiana N.

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Muscat, Joshua

AU - Olshan, Andrew F.

AU - Zevallos, Jose P.

AU - La Vecchia, Carlo

AU - Winn, Deborah M.

AU - Sturgis, Erich M.

AU - Li, Guojun

AU - Fabianova, Eleonora

AU - Lissowska, Jolanda

AU - Mates, Dana

AU - Rudnai, Peter

AU - Shangina, Oxana

AU - Swiatkowska, Beata

AU - Moysich, Kirsten

AU - Zhang, Zuo Feng

AU - Morgenstern, Hal

AU - Levi, Fabio

AU - Smith, Elaine

AU - Lazarus, Philip

AU - Bosetti, Cristina

AU - Garavello, Werner

AU - Kelsey, Karl

AU - McClean, Michael

AU - Ramroth, Heribert

AU - Chen, Chu

AU - Schwartz, Stephen M.

AU - Vaughan, Thomas L.

AU - Zheng, Tongzhang

AU - Menvielle, Gwenn

AU - Boccia, Stefania

AU - Cadoni, Gabriella

AU - Hayes, Richard B.

AU - Purdue, Mark

AU - Gillison, Maura

AU - Schantz, Stimson

AU - Yu, Guo Pei

AU - Brenner, Hermann

AU - D'Souza, Gypsyamber

AU - Gross, Neil D.

AU - Chuang, Shu Chun

AU - Boffetta, Paolo

AU - Hashibe, Mia

AU - Lee, Yuan Chin Amy

AU - Dal Maso, Luigino

PY - 2019/7

Y1 - 2019/7

N2 - Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

AB - Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

KW - Bivariate spline models

KW - Cigarette smoking duration

KW - Cigarette smoking intensity

KW - Head and neck cancer

KW - INHANCE

KW - Laryngeal cancer

KW - Oral cavity and pharyngeal cancers

UR - https://www.scopus.com/pages/publications/85065698410

U2 - 10.1016/j.oraloncology.2019.05.006

DO - 10.1016/j.oraloncology.2019.05.006

M3 - Article

C2 - 31178212

AN - SCOPUS:85065698410

SN - 1368-8375

VL - 94

SP - 47

EP - 57

JO - Oral Oncology

JF - Oral Oncology

ER -

Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

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Keywords

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