Krüppel-like factor 4 (KLF4): What we currently know

Amr M. Ghaleb; Vincent W. Yang

doi:10.1016/j.gene.2017.02.025

Krüppel-like factor 4 (KLF4): What we currently know

Amr M. Ghaleb
, Vincent W. Yang

Medicine, Chair

Stony Brook University

Research output: Contribution to journal › Review article › peer-review

468 Scopus citations

Abstract

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, particularly after it was shown in 2006 as one of four factors involved in the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge about the different functions and roles of KLF4 in various tissue and organ systems.

Original language	English
Pages (from-to)	27-37
Number of pages	11
Journal	Gene
Volume	611
DOIs	https://doi.org/10.1016/j.gene.2017.02.025
State	Published - May 5 2017

Keywords

Cancer
Cell cycle
Differentiation
Diseases
Epithelial-to-mesenchymal transition
Gene expression
Inflammation
KLF4
Organs
Proliferation
Stem cells
Tissues
Transcription

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10.1016/j.gene.2017.02.025

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title = "Kr{\"u}ppel-like factor 4 (KLF4): What we currently know",

abstract = "Kr{\"u}ppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, particularly after it was shown in 2006 as one of four factors involved in the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge about the different functions and roles of KLF4 in various tissue and organ systems.",

keywords = "Cancer, Cell cycle, Differentiation, Diseases, Epithelial-to-mesenchymal transition, Gene expression, Inflammation, KLF4, Organs, Proliferation, Stem cells, Tissues, Transcription",

author = "Ghaleb, \{Amr M.\} and Yang, \{Vincent W.\}",

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year = "2017",

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T1 - Krüppel-like factor 4 (KLF4)

T2 - What we currently know

AU - Ghaleb, Amr M.

AU - Yang, Vincent W.

PY - 2017/5/5

Y1 - 2017/5/5

N2 - Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, particularly after it was shown in 2006 as one of four factors involved in the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge about the different functions and roles of KLF4 in various tissue and organ systems.

AB - Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, particularly after it was shown in 2006 as one of four factors involved in the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge about the different functions and roles of KLF4 in various tissue and organ systems.

KW - Cancer

KW - Cell cycle

KW - Differentiation

KW - Diseases

KW - Epithelial-to-mesenchymal transition

KW - Gene expression

KW - Inflammation

KW - KLF4

KW - Organs

KW - Proliferation

KW - Stem cells

KW - Tissues

KW - Transcription

UR - https://www.scopus.com/pages/publications/85015386366

U2 - 10.1016/j.gene.2017.02.025

DO - 10.1016/j.gene.2017.02.025

M3 - Review article

C2 - 28237823

AN - SCOPUS:85015386366

SN - 0378-1119

VL - 611

SP - 27

EP - 37

JO - Gene

JF - Gene

ER -

Krüppel-like factor 4 (KLF4): What we currently know

Abstract

Keywords

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