TY - GEN
T1 - Lab-on-CMOS capacitance sensor array for real-time cell viability measurements with I2C readout
AU - Senevirathna, Bathiya
AU - Castro, Alexander
AU - Dandin, Marc
AU - Smela, Elisabeth
AU - Abshire, Pamela
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/7/29
Y1 - 2016/7/29
N2 - Capacitance sensing is an emerging technology for monitoring cell viability. This work extends a previously developed sensor that measured capacitive loading by cells on the oscillation frequency of a current-starved ring oscillator and converted the frequency to a digital value by counting oscillation cycles. The new sensor array has been developed into a one-chip lab-on-CMOS system with integrated temperature sensors, serial readout to an external microcontroller using an Inter-Integrated Circuit (I2C) bus, and automatic scanning to allow for autonomous data collection. To allow sensing at the required aF levels, the system was realized on single chip to reduce the baseline capacitance, and long counting times were employed. The I2C module was moved to the edge of the chip prevent exposing cells to unacceptably high temperatures during viability studies.
AB - Capacitance sensing is an emerging technology for monitoring cell viability. This work extends a previously developed sensor that measured capacitive loading by cells on the oscillation frequency of a current-starved ring oscillator and converted the frequency to a digital value by counting oscillation cycles. The new sensor array has been developed into a one-chip lab-on-CMOS system with integrated temperature sensors, serial readout to an external microcontroller using an Inter-Integrated Circuit (I2C) bus, and automatic scanning to allow for autonomous data collection. To allow sensing at the required aF levels, the system was realized on single chip to reduce the baseline capacitance, and long counting times were employed. The I2C module was moved to the edge of the chip prevent exposing cells to unacceptably high temperatures during viability studies.
KW - capacitance measurement
KW - cell culture
KW - lab on a chip
UR - https://www.scopus.com/pages/publications/84983402268
U2 - 10.1109/ISCAS.2016.7539190
DO - 10.1109/ISCAS.2016.7539190
M3 - Conference contribution
AN - SCOPUS:84983402268
T3 - Proceedings - IEEE International Symposium on Circuits and Systems
SP - 2863
EP - 2866
BT - ISCAS 2016 - IEEE International Symposium on Circuits and Systems
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2016 IEEE International Symposium on Circuits and Systems, ISCAS 2016
Y2 - 22 May 2016 through 25 May 2016
ER -