TY - JOUR
T1 - Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens
T2 - Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix
AU - Hall, Amy L.
AU - Kromhout, Hans
AU - Schüz, Joachim
AU - Peters, Susan
AU - Portengen, Lützen
AU - Vermeulen, Roel
AU - Agudo, Antonio
AU - Ahrens, Wolfgang
AU - Boffetta, Paolo
AU - Brennan, Paul
AU - Canova, Cristina
AU - Conway, David I.
AU - Curado, Maria Paula
AU - Daudt, Alexander W.
AU - Fernandez, Leticia
AU - Hashibe, Mia
AU - Healy, Claire M.
AU - Holcatova, Ivana
AU - Kjaerheim, Kristina
AU - Koifman, Rosalina
AU - Lagiou, Pagona
AU - Luce, Danièle
AU - MacFarlane, Gary J.
AU - Menezes, Ana
AU - Menvielle, Gwenn
AU - Polesel, Jerry
AU - Ramroth, Heribert
AU - Richiardi, Lorenzo
AU - Stücker, Isabelle
AU - Thomson, Peter
AU - Vilensky, Marta
AU - Wunsch-Filho, Victor
AU - Yuan-Chin, Amy Lee
AU - Znaor, Ariana
AU - Straif, Kurt
AU - Olsson, Ann
N1 - Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Introduction: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders. Methods: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the International Head and Neck Cancer Epidemiology Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989 to 2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined) and females (asbestos and respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant. Results: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, P values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined); strongest associations were for asbestos at >90th percentile cumulative exposure (OR = 1.3, 95% confidence interval [CI] = 1.0, 1.6), respirable crystalline silica at 30+ years duration (OR = 1.4, 95% CI = 1.2, 1.7) and 75th-90th percentile cumulative exposure (OR = 1.4, 95% CI = 1.1, 1.8), chromium-VI at >75th percentile cumulative exposure (OR = 1.9, 95% CI = 1.2, 3.0), and chromium-VI and nickel combined at 20-29 years duration (OR = 1.5, 95% CI = 1.1, 2.2). Conclusions: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.
AB - Introduction: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders. Methods: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the International Head and Neck Cancer Epidemiology Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989 to 2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined) and females (asbestos and respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant. Results: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, P values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined); strongest associations were for asbestos at >90th percentile cumulative exposure (OR = 1.3, 95% confidence interval [CI] = 1.0, 1.6), respirable crystalline silica at 30+ years duration (OR = 1.4, 95% CI = 1.2, 1.7) and 75th-90th percentile cumulative exposure (OR = 1.4, 95% CI = 1.1, 1.8), chromium-VI at >75th percentile cumulative exposure (OR = 1.9, 95% CI = 1.2, 3.0), and chromium-VI and nickel combined at 20-29 years duration (OR = 1.5, 95% CI = 1.1, 2.2). Conclusions: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.
KW - Asbestos
KW - Case-control studies
KW - chromium(VI)
KW - Laryngeal neoplasms
KW - Nickel
KW - Occupational exposure
KW - Respirable crystalline silica
UR - https://www.scopus.com/pages/publications/85075961863
U2 - 10.1097/EDE.0000000000001120
DO - 10.1097/EDE.0000000000001120
M3 - Article
C2 - 31577634
AN - SCOPUS:85075961863
SN - 1044-3983
VL - 31
SP - 145
EP - 154
JO - Epidemiology
JF - Epidemiology
IS - 1
ER -