Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina.

J. E. Brown; D. C. Watkins; C. C. Malbon

doi:10.1042/bj2470293

Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina.

J. E. Brown
, D. C. Watkins
, C. C. Malbon

Pharmacological Sciences

Washington University St. Louis

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Illumination induced an increase in inositol polyphosphates, inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate, in the photoreceptors of the squid, Loligo pealei. There was a concomitant decrease in phosphatidylinositol 4,5-bisphosphate, but no light-induced change in any other phosphoinositide. None of these stimulus-induced changes were altered by treatment in vivo with pertussis toxin, which ADP-ribosylated a Mr-39000-peptide. These findings support the hypothesis that inositol 1,4,5-trisphosphate participates as either a messenger or a modulator in transduction in invertebrate photoreceptors.

Original language	English
Pages (from-to)	293-297
Number of pages	5
Journal	Biochemical Journal
Volume	247
Issue number	2
DOIs	https://doi.org/10.1042/bj2470293
State	Published - Oct 15 1987

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title = "Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina.",

abstract = "Illumination induced an increase in inositol polyphosphates, inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate, in the photoreceptors of the squid, Loligo pealei. There was a concomitant decrease in phosphatidylinositol 4,5-bisphosphate, but no light-induced change in any other phosphoinositide. None of these stimulus-induced changes were altered by treatment in vivo with pertussis toxin, which ADP-ribosylated a Mr-39000-peptide. These findings support the hypothesis that inositol 1,4,5-trisphosphate participates as either a messenger or a modulator in transduction in invertebrate photoreceptors.",

author = "Brown, \{J. E.\} and Watkins, \{D. C.\} and Malbon, \{C. C.\}",

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AU - Brown, J. E.

AU - Watkins, D. C.

AU - Malbon, C. C.

PY - 1987/10/15

Y1 - 1987/10/15

N2 - Illumination induced an increase in inositol polyphosphates, inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate, in the photoreceptors of the squid, Loligo pealei. There was a concomitant decrease in phosphatidylinositol 4,5-bisphosphate, but no light-induced change in any other phosphoinositide. None of these stimulus-induced changes were altered by treatment in vivo with pertussis toxin, which ADP-ribosylated a Mr-39000-peptide. These findings support the hypothesis that inositol 1,4,5-trisphosphate participates as either a messenger or a modulator in transduction in invertebrate photoreceptors.

AB - Illumination induced an increase in inositol polyphosphates, inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate, in the photoreceptors of the squid, Loligo pealei. There was a concomitant decrease in phosphatidylinositol 4,5-bisphosphate, but no light-induced change in any other phosphoinositide. None of these stimulus-induced changes were altered by treatment in vivo with pertussis toxin, which ADP-ribosylated a Mr-39000-peptide. These findings support the hypothesis that inositol 1,4,5-trisphosphate participates as either a messenger or a modulator in transduction in invertebrate photoreceptors.

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EP - 297

JO - Biochemical Journal

JF - Biochemical Journal

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ER -

Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina.

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