Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Qisi Zhang; Cyrille S. Kounde; Milon Mondal; Jake L. Greenfield; Jennifer R. Baker; Sergei Kotelnikov; Mikhail Ignatov; Christopher P. Tinworth; Leran Zhang; Daniel Conole; Elena De Vita; Dima Kozakov; Adam McCluskey; John D. Harling; Matthew J. Fuchter; Edward W. Tate

doi:10.1039/d2cc03092f

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Qisi Zhang
, Cyrille S. Kounde
, Milon Mondal
, Jake L. Greenfield
, Jennifer R. Baker
, Sergei Kotelnikov
, Mikhail Ignatov
, Christopher P. Tinworth
, Leran Zhang
, Daniel Conole
, Elena De Vita
, Dima Kozakov
, Adam McCluskey
, John D. Harling
, Matthew J. Fuchter
, Edward W. Tate

Applied Mathematics and Statistics

Imperial College London
University of Newcastle
Stony Brook University
GlaxoSmithKline

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.

Original language	English
Pages (from-to)	10933-10936
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	78
DOIs	https://doi.org/10.1039/d2cc03092f
State	Published - Sep 1 2022

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10.1039/d2cc03092f

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Zhang, Q., Kounde, C. S., Mondal, M., Greenfield, J. L., Baker, J. R., Kotelnikov, S., Ignatov, M., Tinworth, C. P., Zhang, L., Conole, D., De Vita, E., Kozakov, D., McCluskey, A., Harling, J. D., Fuchter, M. J., & Tate, E. W. (2022). Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs). Chemical Communications, 58(78), 10933-10936. https://doi.org/10.1039/d2cc03092f

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title = "Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)",

abstract = "Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.",

author = "Qisi Zhang and Kounde, \{Cyrille S.\} and Milon Mondal and Greenfield, \{Jake L.\} and Baker, \{Jennifer R.\} and Sergei Kotelnikov and Mikhail Ignatov and Tinworth, \{Christopher P.\} and Leran Zhang and Daniel Conole and \{De Vita\}, Elena and Dima Kozakov and Adam McCluskey and Harling, \{John D.\} and Fuchter, \{Matthew J.\} and Tate, \{Edward W.\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

month = sep,

day = "1",

doi = "10.1039/d2cc03092f",

language = "English",

volume = "58",

pages = "10933--10936",

journal = "Chemical Communications",

issn = "1359-7345",

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}

Zhang, Q, Kounde, CS, Mondal, M, Greenfield, JL, Baker, JR, Kotelnikov, S, Ignatov, M, Tinworth, CP, Zhang, L, Conole, D, De Vita, E, Kozakov, D, McCluskey, A, Harling, JD, Fuchter, MJ & Tate, EW 2022, 'Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)', Chemical Communications, vol. 58, no. 78, pp. 10933-10936. https://doi.org/10.1039/d2cc03092f

TY - JOUR

T1 - Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

AU - Zhang, Qisi

AU - Kounde, Cyrille S.

AU - Mondal, Milon

AU - Greenfield, Jake L.

AU - Baker, Jennifer R.

AU - Kotelnikov, Sergei

AU - Ignatov, Mikhail

AU - Tinworth, Christopher P.

AU - Zhang, Leran

AU - Conole, Daniel

AU - De Vita, Elena

AU - Kozakov, Dima

AU - McCluskey, Adam

AU - Harling, John D.

AU - Fuchter, Matthew J.

AU - Tate, Edward W.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.

AB - Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.

UR - https://www.scopus.com/pages/publications/85138646980

U2 - 10.1039/d2cc03092f

DO - 10.1039/d2cc03092f

M3 - Article

C2 - 36065962

AN - SCOPUS:85138646980

SN - 1359-7345

VL - 58

SP - 10933

EP - 10936

JO - Chemical Communications

JF - Chemical Communications

IS - 78

ER -

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Abstract

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