Localization of Glycine and Beta-Adrenergic Receptors in the Rat Brain

Masaya Tohyama; Akio Wanaka; Toshiyuki Araki; Heinrich Betz; Caig C. Malbon

doi:10.1679/aohc.52.Suppl_39

Localization of Glycine and Beta-Adrenergic Receptors in the Rat Brain

Masaya Tohyama
, Akio Wanaka
, Toshiyuki Araki
, Heinrich Betz
, Caig C. Malbon

Pharmacological Sciences

The University of Osaka
Heidelberg University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The localization of glycine (GR) and adrenergic receptors (AdR) was examined in the rat brain using a monoclonal antibody against the affinity purified glycine receptor and a polyclonal antibody against purified beta₂-AdR. GR were concentrated in the lower brainstem, whereas no immunoreactivity was observed in the diencephalon and forebrain except in a few diencephalic nuclei. The highest density was found in the cranial motor nuclei, reticular formation, parabrachial area, dorsal and ventral cochlear nuclei, and dorsal and ventral tegmental nuclei. On the other hand, AdR were widely but unevenly distributed in the rat brain. The present study further showed the presence of AdR in catecholaminergic terminals in the hypothalamus.

Original language	English
Pages (from-to)	39-48
Number of pages	10
Journal	Archives of Histology and Cytology
Volume	52
Issue number	Suppl.
DOIs	https://doi.org/10.1679/aohc.52.Suppl_39
State	Published - 1989

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title = "Localization of Glycine and Beta-Adrenergic Receptors in the Rat Brain",

abstract = "The localization of glycine (GR) and adrenergic receptors (AdR) was examined in the rat brain using a monoclonal antibody against the affinity purified glycine receptor and a polyclonal antibody against purified beta2-AdR. GR were concentrated in the lower brainstem, whereas no immunoreactivity was observed in the diencephalon and forebrain except in a few diencephalic nuclei. The highest density was found in the cranial motor nuclei, reticular formation, parabrachial area, dorsal and ventral cochlear nuclei, and dorsal and ventral tegmental nuclei. On the other hand, AdR were widely but unevenly distributed in the rat brain. The present study further showed the presence of AdR in catecholaminergic terminals in the hypothalamus.",

author = "Masaya Tohyama and Akio Wanaka and Toshiyuki Araki and Heinrich Betz and Malbon, \{Caig C.\}",

year = "1989",

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T1 - Localization of Glycine and Beta-Adrenergic Receptors in the Rat Brain

AU - Tohyama, Masaya

AU - Wanaka, Akio

AU - Araki, Toshiyuki

AU - Betz, Heinrich

AU - Malbon, Caig C.

PY - 1989

Y1 - 1989

N2 - The localization of glycine (GR) and adrenergic receptors (AdR) was examined in the rat brain using a monoclonal antibody against the affinity purified glycine receptor and a polyclonal antibody against purified beta2-AdR. GR were concentrated in the lower brainstem, whereas no immunoreactivity was observed in the diencephalon and forebrain except in a few diencephalic nuclei. The highest density was found in the cranial motor nuclei, reticular formation, parabrachial area, dorsal and ventral cochlear nuclei, and dorsal and ventral tegmental nuclei. On the other hand, AdR were widely but unevenly distributed in the rat brain. The present study further showed the presence of AdR in catecholaminergic terminals in the hypothalamus.

AB - The localization of glycine (GR) and adrenergic receptors (AdR) was examined in the rat brain using a monoclonal antibody against the affinity purified glycine receptor and a polyclonal antibody against purified beta2-AdR. GR were concentrated in the lower brainstem, whereas no immunoreactivity was observed in the diencephalon and forebrain except in a few diencephalic nuclei. The highest density was found in the cranial motor nuclei, reticular formation, parabrachial area, dorsal and ventral cochlear nuclei, and dorsal and ventral tegmental nuclei. On the other hand, AdR were widely but unevenly distributed in the rat brain. The present study further showed the presence of AdR in catecholaminergic terminals in the hypothalamus.

UR - https://www.scopus.com/pages/publications/0024848462

U2 - 10.1679/aohc.52.Suppl_39

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M3 - Article

C2 - 2554946

AN - SCOPUS:0024848462

SN - 0914-9465

VL - 52

SP - 39

EP - 48

JO - Archives of Histology and Cytology

JF - Archives of Histology and Cytology

IS - Suppl.

ER -

Localization of Glycine and Beta-Adrenergic Receptors in the Rat Brain

Abstract

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