TY - GEN
T1 - Longitudinal evaluation of the mechanical properties of biomineralized osteoblasts
AU - Meng, Y.
AU - Ba, X.
AU - Ge, S.
AU - Pernodet, N.
AU - Rafailovich, M.
AU - Qin, Y. X.
PY - 2007
Y1 - 2007
N2 - Understanding how biomineralization occurs in the extracellular matrix (ECM) of bone cells is crucial to the development of a successfully engineered bone tissue scaffold, and to date there has not been a well-established method for the quantitative examination of bone mineralization in situ. We investigated the mechanical properties of MC3T3-E1 osteoblast-like cells in vitro using shear modulation force microscopy (SMFM). The elastic modulus of the mineralizing cells increased at time points corresponding to mineral production, whereas that of the non-mineralizing cells did not vary significantly over time.
AB - Understanding how biomineralization occurs in the extracellular matrix (ECM) of bone cells is crucial to the development of a successfully engineered bone tissue scaffold, and to date there has not been a well-established method for the quantitative examination of bone mineralization in situ. We investigated the mechanical properties of MC3T3-E1 osteoblast-like cells in vitro using shear modulation force microscopy (SMFM). The elastic modulus of the mineralizing cells increased at time points corresponding to mineral production, whereas that of the non-mineralizing cells did not vary significantly over time.
UR - https://www.scopus.com/pages/publications/48749114780
U2 - 10.1109/NEBC.2007.4413257
DO - 10.1109/NEBC.2007.4413257
M3 - Conference contribution
AN - SCOPUS:48749114780
SN - 1424410339
SN - 9781424410330
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 15
EP - 16
BT - 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd Annual Northeast Bioengineering Conference, NEBC
Y2 - 10 March 2007 through 11 March 2007
ER -